Search for dissertations about: "Raf"

Showing result 1 - 5 of 35 swedish dissertations containing the word Raf.

  1. 1. Applied bioinformatics for gene characterization

    Author : Raf M. Podowski; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; bioinformatics; gene characterization; text mining; data visualization;

    Abstract : As the vast majority of human protein-encoding genes are now identified, the new challenge placed before life scientists is the determination of the functions of the proteins. Traditionally, intense, directed efforts are applied to decipher the function of a novel protein using laboratory techniques. READ MORE

  2. 2. Krylov methods for nonlinear eigenvalue problems and matrix equations

    Author : Giampaolo Mele; Elias Jarlebring; Raf Vandebril; KTH; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Numerical Analysis; Numerisk analys;

    Abstract : Nonlinear eigenvalue problems (NEPs) arise in many fields of science and engineering. Such problems are often defined by large matrices, which have specific structures, such as being sparse, low-rank, etc. Like the linear eigenvalue problem, the eigenvector appears in a linear form, whereas the eigenvalue appears in a nonlinear form. READ MORE

  3. 3. Affinity protein based inhibition of cancer related signaling pathways

    Author : Erik Vernet; Torbjörn Gräslund; Antonino Cattaneo; KTH; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; Affibody; cancer; endoplasmic reticulum retention; EGFR; HER2; IGF-1R; Raf; Ras; Bioengineering; Bioteknik;

    Abstract : Dysregulation of protein activity, caused by alterations in protein sequence, expression, or localization, is associated with numerous diseases. In order to control the activity of harmful protein entities, affinity ligands such as proteins, oligonucleotides or small molecules can be engineered to specifically interact with them to modulate their function. READ MORE

  4. 4. Ribosome display for selection and evolution of affibody molecules

    Author : Sebastian Grimm; Per-Åke Nygren; Mike Taussig; KTH; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; ribosome display; phage display; combinatorial protein engineering; library; murine IgG1; SATB1; Ras; Raf; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

    Abstract : Affinity proteins are invaluable tools in biotechnological and medical applications. This thesis is about combinatorial protein engineering principles for the generation of novel affinity proteins to purify mouse immunoglobulin, detect a potential cancer marker protein or inhibit a cell proliferation pathway. READ MORE

  5. 5. The Effects of SSRI Treatment on Human Placenta and Embryo

    Author : Helena Kaihola; Helena Åkerud; Inger Sundström-Poromaa; Jocelien Olivier; Olav Spigset; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antenatal depression; embryo; embryo development; fluoxetine; gene expression; NGF; placenta; protein expression; Raf-1; ROCK; signaling pathways; SSRI; Medicinsk vetenskap; Medical Science; Obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : During pregnancy, 4 - 7% of women suffer from major depressive disorder. When antidepressive treatment is needed, selective serotonin reuptake inhibitors (SSRIs) are the most commonly used. Although severe complications from SSRI treatment are rare, association with a number of adverse pregnancy and fetal outcomes has been found. READ MORE