Search for dissertations about: "Raf"

Showing result 16 - 20 of 36 swedish dissertations containing the word Raf.

  2. 16. Molecular Signatures of Cancer

    Author : Esther Edlundh-Rose; Joakim Lundeberg; Peter Södervist; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; : BRAF; NRAS; MGMT; methylation; pyrosequencing; microarray technology; gene expression analysis; Molecular biology; Molekylärbiologi;

    Abstract : Cancer is an important public health concern in the western world, responsible for around 25% of all deaths. Although improvements have been made in the diagnosis of cancer, treatment of disseminated disease is inefficient, highlighting the need for new and improved methods of diagnosis and therapy. READ MORE

  4. 17. Protein Kinase C as an Apoptosis Regulator and a Potential Prognostic Factor in Breast Cancer

    Author : Gry Kalstad Lönne; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Several protein kinase C (PKC) isoforms have been suggested as potential targets for breast cancer therapy. To explore the role for PKC isoforms in processes that facilitates malignant progression and the utility of PKC isoforms as biomarkers in breast cancer, we designed a study where we evaluated the expression of PKCα, δ, and ε in primary breast cancers as well as in breast cancer cell lines. READ MORE

  5. 18. STAT5 expression and regulation in mammary epithelial cells

    Author : Hanne Olsen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : STAT5; JAK2; PPAR-gamma; ER; MAPK; mammary epithelial cell differentiation;

    Abstract : The mammary gland of an adult mammal undergoes cycles of proliferation and differentiation influenced by growth factors, peptide, and steroid hormones, e.g. epidermal growth factor (EGF), prolactin (PRL) and estrogen (E). READ MORE

  6. 19. Mechanisms of insulin signaling and the role of caveolae

    Author : Santiago Parpal; Pam Fredman; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Insulin regulates metabolic as well as mitogenic processes in target cells, involving a large number of mediators of signal transduction. In its role as a growth factor, insulin stimulates cell growth, in a process we demonstrate requires the participation of the Raf-1 kinase. READ MORE

  7. 20. Experimental studies on ErbB targeted therapy in malignant melanoma

    Author : Emelie Severinsson; Thomas Walz; Anna-Lotta Hallbeck; Olle Stål; Olle Larsson; Linköpings universitet; []
    Keywords : ;

    Abstract : Malignant melanoma has one of the fastest increasing incidences among the different types of cancer in the Western world. This raise can partly be ascribed to the change in sun habits that has taken place during the last decades, since the major external risk factor for melanoma is exposure to ultraviolet radiation. READ MORE