Search for dissertations about: "Ralf Morgenstern"

Showing result 6 - 8 of 8 swedish dissertations containing the words Ralf Morgenstern.

2. 6. The Quest for Functional Quasi-Species in Glutathione Transferase Libraries

   Author : Arna Rúnarsdóttir; Bengt Mannervik; Ralf Morgenstern; Uppsala universitet; []
   Keywords : glutathione transferase; directed evolution; multivariate analysis; quasi-species; isothiocyanates; Biokemi; Biochemistry;

   Abstract : Glutathione transferases (GSTs) are good candidates for investigations of enzyme evolution, due to their broad substrate specificities and structural homology. The primary role of GSTs is to act as phase II detoxifying enzymes protecting the cell from toxic compounds of both endo- and exogenous origins. READ MORE

4. 7. The enzymatic machinery of leukotriene biosynthesis : Studies on ontogenic expression, interactions and function

   Author : Tobias Strid; Sven Hammarström; Mats Söderström; Ralf Morgenstern; Linköpings universitet; []
   Keywords : ;

   Abstract : Leukotrienes (LTs) are biologically active arachidonic acid (AA) derivatives generated by the 5-lipoxygenase (5-LO) pathway. They are produced by myeloid cells. 5-LO converts AA to LTA4 in cooperation with 5-LO activating protein (FLAP). LTA4 is converted to LTB4, by LTA4-hydrolase (LTA4H) or to LTC4 by LTC4-synthase (LTC4S). READ MORE

5. 8. Mechanisms of formation and protection against oxidative DNA damage in vitro and in vivo

   Author : Peter Svoboda; Ralf Morgenstern; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physical Biology; fysikalisk biologi;

   Abstract : Oxidative DNA damage has been linked to cancer and aging as well as other diseases. The aim of this thesis was to study the mechanisms for DNA damage generated in cells or in vitro systems by ionizing radiation or transition metals like iron ions. READ MORE