Search for dissertations about: "Ras"

Showing result 21 - 25 of 200 swedish dissertations containing the word Ras.

  2. 21. Prognostic and Predictive Factors in Metastatic Colorectal Cancer

    Author : Emerik Österlund; Tobias Sjöblom; Bengt Glimelius; Peter Nygren; Torben Frøstrup Hansen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metastatic colorectal cancer; RAS mutations; BRAF mutations; biomarkers; outcome;

    Abstract : The outcome for metastatic colorectal cancer (mCRC) patients has improved substantially in recent decades. This has chiefly been observed in study populations, and predominantly in left-sided primary tumours, which is why we wanted to study if and how survival has improved in the background population. READ MORE

  4. 22. Notch Signaling in Human Neuroblastoma Cells

    Author : Marie Stockhausen; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Hes-1; Medicin människa och djur ; Medicine human and vertebrates ; hypoxia; TGF-alpha; EGFR; ERK1 2; Ras MAPK; differentiation; valproic acid; ubiquilin-1; neuroblastoma; Hash-1; Cytologi; onkologi; cancer; cancerology; Cytology; Notch;

    Abstract : Neuroblastoma is a childhood tumor derived from the sympathetic nervous system (SNS). It is believed that the tumors arise from cells halted in their differentiation and due to their immature phenotype; they express proteins normally only detected during embryogenesis. One such protein is Hash-1, which is required for formation of the SNS. READ MORE

  5. 23. Detection and analysis of genetic alterations in normal skin and skin tumours

    Author : Åsa Sivertsson; KTH; []
    Keywords : single cell; DNA sequencing; p53; mutation; UV; BCC; pyrosequencing; malignant melanoma; N-ras;

    Abstract : The investigation of genetic alterations in cancer-relatedgenes is useful for research, prognostic and therapeuticpurposes. However, the genetic heterogeneity that often occursduring tumour progression can make correct analysischallenging. READ MORE

  6. 24. Studies of induced transcription in response to an activated Ha-ras, TPA and UV radiation in keratinocytes

    Author : Mats Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : keratinocytes; Ha-ras; ultraviolet radiation; transcription factor; TPA; NF-kB;

    Abstract : The mutational activation of the Ha-ras gene in keratinocytes has been shown to occur during the initiation step in the mouse skin model for multistage carcinogenesis. Skin tumor promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and ultraviolet radiation (UVR) stimulate a selective outgrowth of initiated keratinocytes to form benign tumours (papillomas). READ MORE

  7. 25. Expression of ras and p53, DNA ploidy and 5-phase fraction in human colorectal adenocarcinoma

    Author : Xiao-Feng Sun; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The accumulation of oncogene and anti-oncogene alterations play an important role in the development of colorectal adenocarcinomas. These specific gene alterations cause changes of DNA ploidy and cell proliferation and, in turn, DNA instability might lead to more genetic changes. READ MORE