Search for dissertations about: "Rat brain tumor"

Showing result 1 - 5 of 33 swedish dissertations containing the words Rat brain tumor.

  1. 1. NO, Immunosuppression and Tumor Immmunotherapy

    University dissertation from Pontus Hegardt, BMC I:12, 221 84 Lund

    Author : Pontus Hegardt; Lund University.; Lunds universitet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; IL-18; IFN-gamma; rat; colon carcinoma; glioma; tumor immunotherapy; immunosuppression; NO; iNOS;

    Abstract : This study aims at clarifying the role of NO in the immunosuppression induced by in vivo tumor growth and by tumor immunotherapy, and determining whether the inhibition of NO production can be used as an adjuvant in tumor immunotherapy. We have shown previously that tumor cells, glioma (N32) and colon carcinoma (H1D2), when genetically engineered to express such immune stimulatory cytokines as IFN-g and IL-18, induce strong anti-tumor immune response, in immunized tumor-free rats, whereas only a limited therapeutic effect is achieved in rats in which a tumor has already become established. READ MORE

  2. 2. Immuno Gene Therapy of Rat Brain Tumors with interferon-gamma transfected glioma cells

    University dissertation from Edward Visse BMC-ImmunbiologiTumör ImmunologiSölvegatan 21223 62 LundSweden

    Author : Edward Visse; Lund University.; Lunds universitet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; transplantation; serologi; Immunologi; Immunotherapy; Rat brain tumor; Interferon-gamma; isograft rejection; tumor infiltrating lymphocytes; Immunization; Immunology; serology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Immunotherapy is a new promising approach in cancer treatment. In the future, it will hopefully offer an alternative to existing brain tumors treatments, which are unable to cure. We have established an experimental, low immunogenic, brain tumor model in the rat. READ MORE

  3. 3. Experimental brain tumors, dendritic cells and immunotherapy

    University dissertation from Lund University

    Author : Shorena Janelidze; Lund University.; Lunds universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dendritic cell; interferon-γ; immunotherapy; Brain tumor;

    Abstract : Malignant astrocytomas are the most common primary tumors of the adult central nervous system. Surgical resection of tumor mass in combination with radiotherapy and chemotherapy is only palliative and there is a clear need for new and more effective therapeutic strategies. READ MORE

  4. 4. Stem cell based therapy of malignant brain tumors

    University dissertation from Avd för Neurokirurgi, Inst för kliniska vetenskaper, Medicinska fakulteten, Lunds Universitet

    Author : Daniel Bexell; Lund University.; Lunds universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neural stem cell; pericyte; mesenchymal stem cell; neuroblast; subventricular zone; cancer stem cell; rat; glioma; cancer;

    Abstract : Malignant brain tumor is a highly invasive and vascularized cancer. Current forms of therapy are not curative and can, at best, prolong survival for patients with this disease. The mean survival is only around 15 months. READ MORE

  5. 5. DNA repair and the p53 pathway in ischemic and traumatic brain injury

    University dissertation from Experimental Brain Research, Lund University

    Author : Gregor Tomasevic; Lund University.; Lunds universitet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuronal death; DNA repair; knock-out mice; XPA; p53; mRNA; hippocampus; preconditioning; hypothermia; trauma; Brain; ischemia; neurobehavior; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Ischemic and traumatic brain damage are major causes of disability and death. While much effort has been spent to develop pharmacological treatments for these conditions, no neuroprotective drugs are in clinical use. READ MORE