Search for dissertations about: "Rational design"

Showing result 1 - 5 of 188 swedish dissertations containing the words Rational design.

  1. 1. Catalysis and Site-Specific Modification of Glutathione Transferases Enabled by Rational Design

    Author : Sofia Håkansson Hederos; Lars Baltzer; Kerstin Broo; Linköpings universitet; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Catalysis; Glutathione Transferases; Rational design; Protein design; Site-specific modification; thiolester hydrolysis; Enzyme engineering; Enzymteknik;

    Abstract : This thesis describes the rational design of a novel enzyme, a thiolester hydrolase, derived from human glutathione transferase (GST) A1-1 by the introduction of a single histidine residue. The first section of the thesis describes the design and the determination of the reaction mechanism. READ MORE

  2. 2. Protein Engineering by Directed Evolution and Rational Design

    Author : Torbjörn Gräslund; KTH; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ion-exchange chromatography; subtilisin; Klenow DNA polymerase; Taq DNA polymerase; directed evolution; rational design; charge engineering; phosphonylating inhibitor; phage display; circular dichroism; protein A; Bioengineering; Bioteknik;

    Abstract : .... READ MORE

  3. 3. On the Nature and Origin of Recognition in Molecularly Imprinted Polymers. : Paths Towards Their Rational Design

    Author : Håkan S. Andersson; Ann-Christin Koch-Schmidt; Klaus Mosbach; Maria Kempe; Högskolan i Kalmar; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molecular imprinting; molecular recognition; Biokemi; Biochemistry;

    Abstract : .... READ MORE

  4. 4. Holistic approach in engineering design - controlling risks from accidental hazards in bridge design

    Author : Ivar Björnsson; Avdelningen för Konstruktionsteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; design; codes; accidental; extreme; bridges; holistic; approach; robustness; risk; reliability; uncertainty;

    Abstract : Engineering design, in concise terms, is what engineers do using what they know. It is the underlying decision making activity that determines what is to be built and how it should be built. An ever present requirement in engineering design is that the structure should be safe. READ MORE

  5. 5. Computational Methods in Conceptual Structural Design

    Author : Vedad Alic; Byggnadsmekanik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; ENGINEERING AND TECHNOLOGY; conceptual design; conceptual structural design; ground-borne vibrations; form finding; optimization; dynamic relaxation; graphic statics; reciprocal figures; strut-and-tie; finite element method; isogeometric analysis; NURBS; CAD; numerical modelling;

    Abstract : Conceptual design is the first phase in the design process in which all the requirements and design objectives are synthesized into conceptual alternatives. In practice today, major decisions regarding the buildings function, massing, and overall form are usually made during the first phase. READ MORE