Search for dissertations about: "Rational design"

Showing result 16 - 20 of 210 swedish dissertations containing the words Rational design.

  2. 16. Modified Glycopeptides Targeting Rheumatoid Arthritis : Exploring molecular interactions in class II MHC/glycopeptide/T-cell receptor complexes

    Author : Ida E. Andersson; Jan Kihlberg; Anna Linusson Jonsson; Craig Crews; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Major histocompatibility complex; class II MHC; T-cell receptor; rheumatoid arthritis; collagen-induced arthritis; glycopeptide; amide bond isostere; comparative modeling; rational design; molecular docking; molecular dynamics simulation; statistical molecular design; Bioorganic chemistry; Bioorganisk kemi; organisk kemi; Organic Chemistry; Biorganic Chemistry; bioorganisk kemi; datorlingvistik; computational linguistics;

    Abstract : Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that leads to degradation of cartilage and bone mainly in peripheral joints. In collagen-induced arthritis (CIA), a mouse model for RA, activation of autoimmune CD4+ T cells depends on a molecular recognition system where T-cell receptors (TCRs) recognize a complex between the class II MHC Aq protein and CII259-273, a glycopeptide epitope from type II collagen (CII). READ MORE

  4. 17. Towards the Rational Design of Molecularly Imprinted Polymers

    Author : Håkan S Andersson; Ann-Christin Koch-Schmidt; Ian A Nicholls; Klaus Mosbach; Richard F Venn; Tillämpad biokemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Thermodynamics; Molecular Recognition; Polyvalency; Cooperativity; Electrostatic Interactions; Hydrophobic Effect; Chromatography; Frontal Analysis; HPLC; Spectroscopy; Molecularly Imprinted Polymer; Molecular Imprinting; Crown Ether; Template Polymerisation; Cyclodextrin; Biochemistry; Metabolism; Biokemi; Biotechnology; Bioteknik; molecular recognition; Biokemi;

    Abstract : Molecular imprinting is a technique by which polymeric materials selective for a given target molecule can be created through a casting procedure. Functionalised monomers are added to a solution of molecular templates. READ MORE

  5. 18. On Catalytic Mechanisms for Rational Enzyme Design Strategies

    Author : Charlotte Kürten; Per-Olof Syrén; Rudolf Allemann; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; catalytic mechanisms; terpene cyclase; triterpene cyclase; solvent dynamics; protein hydration; thermodynamics; quantum tunneling; polycyclization; natural compounds; ? ?-hydrolase; esterase; amidase; enzyme engineering; biocatalysis; Bioteknologi; Biotechnology;

    Abstract : Enzymes enable life by promoting chemical reactions that govern the metabolism of all living organisms. As green catalysts, they have been extensively used in industry. However, to reach their full potential, engineering is often required, which can benefit from a detailed understanding of the underlying reaction mechanism. READ MORE

  6. 19. Rational design and applications of cell-penetrating peptides

    Author : Jakob Regberg; Ülo Langel; Amelie Eriksson Karlström; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Cell-penetrating peptides are peptides capable of translocating the cellular membrane and entering the cell, either alone or together with a cargo. Potential applications of cell-penetrating peptides include drug delivery and gene therapy. READ MORE

  7. 20. On design of low order H-infinity controllers

    Author : Daniel Ankelhed; Anders Hansson; Anders Helmersson; Jakob Stoustrup; Linköpings universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; H-infinity synthesis; linear systems; linear matrix inequalities; rank constraints; optimization; rational constraints; interior point methods; Automatic control; Reglerteknik;

    Abstract : When designing controllers with robust performance and stabilization requirements, H-infinity synthesis is a common tool to use. These controllers are often obtained by solving mathematical optimization problems. The controllers that result from these algorithms are typically of very high order, which complicates implementation. READ MORE