Search for dissertations about: "Rational design"

Showing result 6 - 10 of 210 swedish dissertations containing the words Rational design.

  2. 6. Computational Methods in Conceptual Structural Design

    Author : Vedad Alic; Byggnadsmekanik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; conceptual design; conceptual structural design; ground-borne vibrations; form finding; optimization; dynamic relaxation; graphic statics; reciprocal figures; strut-and-tie; finite element method; isogeometric analysis; NURBS; CAD; numerical modelling;

    Abstract : Conceptual design is the first phase in the design process in which all the requirements and design objectives are synthesized into conceptual alternatives. In practice today, major decisions regarding the buildings function, massing, and overall form are usually made during the first phase. READ MORE

  4. 7. Exploiting enzyme promiscuity for rational design

    Author : Cecilia Branneby; Karl Hult; Alex Zaks; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Candida antarctica lipase B; alanine racemase; substrate specificity; reaction specificity; enzyme catalytic promiscuity; Biokemi; Biochemistry; Biokemi;

    Abstract : Enzymes are today well recognized in various industrial applications, being an important component in detergents, and catalysts in the production of agrochemicals, foods, pharmaceuticals, and fine chemicals. Their large use is mainly due to their high selectivity and environmental advantage, compared to traditional catalysts. READ MORE

  5. 8. Selective inhibition of acetylcholinesterase 1 from disease-transmitting mosquitoes : design and development of new insecticides for vector control

    Author : Cecilia Engdahl; Anna Linusson; Fredrik Ekström; Zoran Radić; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; non-covalent inhibitor; vector control; insecticide; mosquito; vector-borne disease; high throughput screening; rational design; biokemi; Biochemistry; datorlingvistik; computational linguistics;

    Abstract : Acetylcholinesterase (AChE) is an essential enzyme with an evolutionary conserved function: to terminate nerve signaling by rapid hydrolysis of the neurotransmitter acetylcholine. AChE is an important target for insecticides. READ MORE

  6. 9. Negotiating the value(s) of design(ing): An organisational inquiry

    Author : Ulises Navarro Aguiar; Göteborgs universitet; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; design; strategy; practice; valuation; value; power; agency;

    Abstract : Organisations are increasingly calling upon design as a strategic asset to generate innovation as part of a wider fascination with ‘design thinking’ in business. Recent scholarship has tended to emphasise design’s many contributions to business and society, playing a part in the growing recognition and expansion of design as an idea. READ MORE

  7. 10. Rational design of novel cell-penetrating peptides

    Author : Staffan Lindberg; Ülo Langel; Lena Mäler; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Although cell-penetrating peptides (CPPs) have been an active field of research for over 20 years there are still properties such as efficiency and stability that must be improved for CPPs to reach their full potential as delivery vectors.In this thesis two peptides were designed for non-covalent oligonucleotide delivery, in an attempt to overcome two major issues hampering wider use of CPPs, namely low stability and endosomal entrapment. READ MORE