Search for dissertations about: "Reading frame maintenance"
Showing result 1 - 5 of 6 swedish dissertations containing the words Reading frame maintenance.
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1. Wobble modifications and other features in transfer RNA important for decoding and reading frame maintenance
Abstract : Transfer RNA (tRNA) is the adaptor molecule responsible for bringing the correct amino acid to the ribosome during protein synthesis. tRNA contains a number of modified nucleosides, which are derivatives of the four normal nucleosides. READ MORE
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2. Functional aspects of modified nucleosides in tRNA
Abstract : Transfer ribonucleic acids (tRNAs) are extensively modified, especially their anticodon loops. Modifications at position 34 (wobble base) and 37 in these loops affect the tRNAs’ decoding ability, while modifications outside the anticodon loops, e.g. m1A58 of tRNAMeti, may be crucial for tRNA structure or stability. READ MORE
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3. Structural and Biochemical Studies of Antibiotic Resistance and Ribosomal Frameshifting
Abstract : Protein synthesis, translation, performed by the ribosome, is a fundamental process of life and one of the main targets of antibacterial drugs. This thesis provides structural and biochemical understanding of three aspects of bacterial translation.Elongation factor G (EF-G) is the target for the antibiotic fusidic acid (FA). READ MORE
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4. Frameshifting as a tool in analysis of transfer RNA modification and translation
Abstract : Studies of ribosomal reading frame maintenance are often based on frameshift mutation suppression experiments. In this thesis, suppression of a frameshift mutation in Salmonella enterica serovar Typhimurium by a tRNA and a ribosomal protein are described. READ MORE
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5. Biased Evolution : Causes and Consequences
Abstract : In evolution alternative genetic trajectories can potentially lead to similar phenotypic outcomes. However, certain trajectories are preferred over others. These preferences bias the genomes of living organisms and the underlying processes can be observed in ongoing evolution. READ MORE