Search for dissertations about: "Receptor Tyrosine Kinase MET"

Showing result 1 - 5 of 10 swedish dissertations containing the words Receptor Tyrosine Kinase MET.

  2. 1. The receptor tyrosine kinase Met and the protein tyrosine phosphatase PTPN2 in breast cancer

    Author : Cynthia Veenstra; Olle Stål; Gizeh Perez-Tenorio; Pietras Kristian; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Breast cancer is the most common form of cancer in women worldwide and the second leading cause of cancer death. It is a heterogeneous disease and is subdivided into different subtypes, all with different treatment responses and survival outcomes. READ MORE

  4. 2. A microscopic investigation of miR-34c and miR-205 in Prostate Cancer

    Author : Zandra Hagman; Malmö Klinisk kemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microRNA; prostate cancer; androgen receptor; MET; HGF; miR-34c; miR-205; AGO2-RIP-Chip; noncoding RNA;

    Abstract : The complex genetics of cancer allows tumors to grow and spread undeterred by the control mechanisms of the cell. The importance of protein-coding genes in tumorigenesis is well established. READ MORE

  5. 3. Mechanisms determining efficacy of tyrosine kinase-targeting anti-cancer drugs

    Author : Maja Bradic Lindh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The expanding field of cancer research and the introduction of multiple molecular biology techniques have significantly improved cancer drug discovery, presented new drugs, including tyrosine kinase inhibitors, and thereby gave new hope to the cancer patients and their oncologists. Using this knowledge it is now becoming increasingly possible to determine outcome of malignant disease more accurately, to estimate response to specific therapies and to get closer to the ideal of personalized targeted therapy adjusted to each patient, and to the specific cancer type and its unique genetic profile. READ MORE

  6. 4. GDNF and its receptors : a structure-function analysis of the NCAM-GDNF-GFRalpha1 complex and an examination of potential receptor candidates

    Author : Dan Sjöstrand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neurotrophic factors are small, secreted proteins that are important players in the development and maintenance of the nervous system. Their functions span from neuronal survival and migration to neurite outgrowth and axon guidance, and in some cases even programmed cell death. READ MORE

  7. 5. Cryo-electron tomography of individual protein molecules

    Author : Sara Sandin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cryo-Electron Microscopy; Cryo-Electron Tomography; Protein Conformation; Antibodies; Immunoglobulin G; Glucocorticoid Receptor; Hepatocyte Growth Factor Scatter Factor; Receptor Tyrosine Kinase MET;

    Abstract : Averaging methods of determining structure, such as X-ray diffraction, do not preserve information about the flexibility of molecules. Cryo-electron tomography allows us to reconstruct individual hydrated objects. READ MORE