Search for dissertations about: "Receptor Tyrosine Kinase MET"

Showing result 6 - 10 of 10 swedish dissertations containing the words Receptor Tyrosine Kinase MET.

  2. 6. Control of neuronal survival, migration and outgrowth by GDNF and its receptors

    Author : Maurice Perrinjaquet; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Glial cell line-derived neurotrophic factor (GDNF) is the prototypical member of a family of growth factors that are indispensable in nervous system development and maintenance. GDNF signals by binding to a multi-component receptor complex comprised of the ligand-binding subunit GFRα1 and the signaling subunit RET or NCAM. READ MORE

  4. 7. Regulation of internalization and replication of intracellular bacterial pathogens

    Author : Eugénie Bassères; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The capacity of intracellular bacteria to cause disease depends on their ability to invade and replicate within eukaryotic host cells. These characteristics also allow preferential invasion and replication by facultative anaerobic bacteria in solid tumours, which can be exploited to design delivery vectors for cancer therapy. READ MORE

  5. 8. Investigations of Leucine-rich repeats and immunoglobulin-like domain-proteins 1 and 2 (LRIG1 and LRIG2) and their genes in cancer

    Author : Mahmood Faraz; Håkan Hedman; Roger Henriksson; Rolf Bjerkvig; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LRIG1; LRIG2; PDGFR; glioma; interactome; breast cancer; prognosis; Oncology; onkologi;

    Abstract : The mammalian leucine-rich repeats and immunoglobulin-like domains (LRIG) gene family consists of three different members, LRIG1, LRIG2, and LRIG3. These genes are expressed in all human and mouse tissues analyzed to date. READ MORE

  6. 9. Transcriptomic and functional studies of fusion oncogene-driven salivary gland tumors

    Author : Maryam K. Afshari; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fusion oncogene; MYB; NFIB; PLAG1; HMGA2; adenoid cystic carcinoma; pleomorphic adenoma; targeted therapy;

    Abstract : Fusion genes are potent oncogenic drivers resulting from exchange of regulatory/coding sequences between two genes. They were originally identified in leukemias but are now recognized as key oncogenic events also in many solid tumors, including salivary gland tumors (SGTs). READ MORE

  7. 10. Development of novel DNA vaccine and immunotherapeutic approaches

    Author : Maroof Hasan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Many potential DNA vaccination and immunotherapeutic strategies has been explored in both animal models and human settings in recent years. However, the failure of efficient and safe method development suggests that it is time to rethink, since more innovative approaches are needed for better control of infection and immunotherapy. READ MORE