Search for dissertations about: "Recombinant antibody"

Showing result 1 - 5 of 160 swedish dissertations containing the words Recombinant antibody.

2. 1. Systems enabling antibody-mediated proteomics research

   Author : Ronny Falk; Sophia Hober; Christer Wingren; KTH; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibody generation; dual expression; affinity purification; E. coli expression; Affibody molecules; polyclonal antibody; monospecific antibody; Immunobiology; Immunbiologi;

   Abstract : As many genome sequencing efforts today are completed, we are now provided with the genetic maps for several organisms, including man. With these maps at hand, the scientific focus is now shifting towards investigations of the functionality of proteins. READ MORE

4. 2. Molecular Recognition in Antibody Engineering. Studies on recombinant and phage displayed antibodies

   Author : Ann-Christin Malmborg Hager; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; affinity; antibody; kinetic; Immunologi; serologi; serology; Immunology; Bioteknik; Biotechnology; library; selection; surface display; phage display; association rate; dissociation rate;

   Abstract : In vitro generation of antibody fragments of desired specificity and affinity plays an important role since it permits the generation of reagents which may be valuable for diagnostic and therapeutic applications. Furthermore, the kinetic parameters for an antibody-antigen interaction, rather than the affinity, has shown to correlate with biological functions like virus neutralization. READ MORE

5. 3. Design of recombinant antibody microarrays for global proteome analysis

   Author : Johan Ingvarsson; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bioteknik; oncoproteomics; Recombinant antibody microarray; scFv; Biotechnology; plasma proteome analysis;

   Abstract : Antibody-based microarrays are among the new, rapidly emerging technologies within the field of proteomics that has the potential to evolve into a key proteomic research tool, providing novel means to perform early diagnostics, identify biomarkers and gain insights into disease biology. The aim of this thesis, based on five original papers, was to develop antibody microarrays based on human recombinant scFv antibody fragments for large-scale comprehensive proteome analysis. READ MORE

6. 4. Recombinant subunit vaccines : protein immunogens

   Author : Sissela Liljeqvist; KTH; []
   Keywords : ;

   Abstract : Recombinant techniques provide valuable tools for thedevelopment of modern subunit vaccines. In this thesisdifferent systems for production of recombinant subunitvaccines are presented. The strategies investigated includeprotein immunogens, live bacterial vectors and nucleicacids. READ MORE

7. 5. Characterization of antibody specificity using peptide array technologies

   Author : Björn Forsström; Mathias Uhlén; Markus Templin; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibody; Epitope mapping; Peptide array; Suspension bead array; Antigen; Specificity; Cross-reactivity; Immunization; Immunogenicity; Bioteknologi; Biotechnology;

   Abstract : Antibodies play an important role in the natural immune response to invading pathogens. The strong and specific binding to their antigens also make them indispensable tools for research, diagnostics and therapy. READ MORE