Search for dissertations about: "Regulatory Sequences"

Showing result 1 - 5 of 98 swedish dissertations containing the words Regulatory Sequences.

  1. 1. Computational and experimental approaches to regulatory genetic variation

    University dissertation from Stockholm : Bioteknologi

    Author : Malin Andersen; KTH.; [2007]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Molecular biology; Genetics; single nucleotide polymprhism SNP ; regulatory SNP; transcription factor binding site; phylogenetic footprinting; allelic imbalance; EMSA; CD36; cardiovascular disease.; TECHNOLOGY Bioengineering Genetic engineering including functional genomics; TEKNIKVETENSKAP Bioteknik Genteknik inkl. funktionsgenomik;

    Abstract : Genetic variation is a strong risk factor for many human diseases, including diabetes, cancer, cardiovascular disease, depression, autoimmunity and asthma. Most of the disease genes identified so far alter the amino acid sequences of encoded proteins. READ MORE

  2. 2. In silico prediction of CIS-regulatory elements

    University dissertation from Stockholm : Karolinska Institutet, Center for Genomics Research

    Author : Albin Sandelin; Karolinska Institutet.; Karolinska Institutet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transcriptional regulation; transcription factor binding sites; phylogenetic footprinting; pattern finding; pattern comparison;

    Abstract : As one of the most fundamental processes for all life forms, transcriptional regulation remains an intriguing and challenging subject for biomedical research. Experimental efforts towards understanding the regulation of genes is laborious and expensive, but can be substantially accelerated with the use of computational predictions. READ MORE

  3. 3. Gene complexes and regulatory domains in metazoan genomes

    University dissertation from Stockholm : Karolinska Institutet, Department of Cell and Molecular Biology

    Author : Pär Engström; Karolinska Institutet.; Karolinska Institutet.; [2007]

    Abstract : Despite the recent massive increases in genome and transcript sequence data, including wholegenome sequences for humans and many other metazoans, our understanding of the content of these sequences is far from complete. This thesis is about making use of metazoan sequence data to detect functional genetic elements on a genome-wide scale and examine the distribution of those elements on chromosomes. READ MORE

  4. 4. Computational Modelling of Gene Regulation in Cancer Coding the noncoding genome

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Husen Muhammad Umer; Uppsala universitet.; [2018]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Regulatory elements; gene regulation; cancer; motif; integrative database; software solutions for cancer data; Bioinformatics; Bioinformatik;

    Abstract : Technological advancements have enabled quantification of processes within and around us. The information stored within our body converts into petabytes of data. Processing and learning from such data requires comprehensive computational programs and software systems. READ MORE

  5. 5. On diverse biophysical aspects of genetics from the action of regulators to the characterization of transcripts

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Aymeric Fouquier D´Hérouel; KTH.; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; transcription regulation; regulatory motifs; binding affinity; genetic interactions; secondary structure; sequence repeats; transcript characterization; NATURAL SCIENCES Physics Condensed matter physics Biological physics; NATURVETENSKAP Fysik Kondenserade materiens fysik Biologisk fysik;

    Abstract : Genetics is among the most rewarding fields of biology for the theoretically inclined, offering both room and need for modeling approaches in the light of an abundance of experimental data of different kinds. Many aspects of the field are today understood in terms of physical and chemical models, joined by information theoretical descriptions. READ MORE