Search for dissertations about: "Regulatory Sequences"

Showing result 6 - 10 of 109 swedish dissertations containing the words Regulatory Sequences.

2. 6. Regulation of protein degradation by virus derived repeated amino acid sequences

   Author : Ainars Leonchiks; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Epstein-Barr virus; glycine-alanine repeat; ubiquitin-proteasome pathway;

   Abstract : The ubiquitin-proteasome pathway plays a central role in the controlled degradation of short-lived and regulatory proteins important m a variety of cellular processes, including antigen presentation and combating viral infections. The presentation of antigenic peptides derived from ubiquitin-proteasome dependent degradation of vital proteins to MHC class I restricted cytotoxic T cells is a central component of antiviral responses. READ MORE

4. 7. Gene regulatory evolution in flycatchers: statistical approaches for the analysis of allele-specific expression

   Author : Mi Wang; Hans Ellegren; Christopher Wheat; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; ASE; gene expression evolution; bayesian; RPASE; flycatcher.; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

   Abstract : Understanding the molecular mechanisms underlying evolutionary changes in gene expression is a major research topic in biology. While a powerful approach to study this is the analysis of allele-specific expression (ASE), most of previously published methods can only be applied to lab organisms. READ MORE

5. 8. A genomic approach to smooth muscle differentiation and diversity

   Author : Sven Nelander; Göteborgs universitet; []
   Keywords : Keywords: smooth muscle; phenotype; transcriptional regulation; differentiation; transcriptome; microarray; computational prediction; co-expression network; regulatory sequence analysis; gene module; gene battery;

   Abstract : Smooth muscle cells (SMCs) are a broad class of contractile cells that are found in a number of organs systems, including the vasculature, the urogenital system, the bronchi and the gastrointestinal tract. The two main functions exerted by SMCs are to provide contractile force and to synthesize structural components of the extracellular matrix. READ MORE

6. 9. Studies on the Molecular Biology of the Mouse Pneumotropic Polyomavirus

   Author : Shouting Zhang; Kristina Dörries; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; murine pneumotropic virus; Kilham mouse polyomavirus; large T antigen; enhancer; regulatory region rearrangement; gene expression regulation; DNA replication; transposable elements; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Abstract : The Murine Pneumotropic Virus (MPtV), in contrast to the other MurinePolyomavirus (MPyV), appears to be non-tumourigenic in its natural host. Instead, MPtV causes acute pneumonia and can serve as a model in studies of polyomavirus-induced disease. In initial experiments, MPtV large T-antigen (LT) was expressed in a heterologous system. READ MORE

7. 10. Advances in studying the role of genetic divergence and recombination in adaptation in non-model species

   Author : Ramprasad Neethiraj; Christopher Wheat; Sören Nylin; Mathieu Joron; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Recombination; Genetic divergence; Lepidoptera; Genetic variation; Genetic diversity; Holocentric chromosomes; cis-regulatory variation; Allele-specific expression; populationsgenetik; Population Genetics;

   Abstract : Understanding the role of genetic divergence and recombination in adaptation is crucial to understanding the evolutionary potential of species since they can directly affect the levels of genetic variation present within populations or species. Genetic variation in the functional parts of the genome such as exons or regulatory regions is the raw material for evolution, because natural selection can only operate on phenotypic variation already present in the population. READ MORE