Search for dissertations about: "Regulatory State"

Showing result 26 - 30 of 218 swedish dissertations containing the words Regulatory State.

  2. 26. A step forward in using QSARs for regulatory hazard and exposure assessment of chemicals

    Author : Aleksandra Rybacka; Patrik Andersson; Christina Rudén; Anna Linusson; Uko Maran; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; QSAR; in silico; non-testing tools; risk assessment; exposure assessment; hazard assessment; carcinogenicity; mutagenicity; reproductive toxicity; endocrine disruption; estrogen; androgen; transthyretin; sorption; Environmental Science; miljövetenskap; Computer Science; datalogi; Toxicology; toxikologi; Statistics; statistik;

    Abstract : According to the REACH regulation chemicals produced or imported to the European Union need to be assessed to manage the risk of potential hazard to human health and the environment. An increasing number of chemicals in commerce prompts the need for utilizing faster and cheaper alternative methods for this assessment, such as quantitative structure-activity or property relationships (QSARs or QSPRs). READ MORE

  4. 27. Conversations on accounting practices : a study of an enforcement body in a time of regulatory change

    Author : Anna-Stina Gillqvist; Handelshögskolan i Stockholm; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES;

    Abstract : When EU adopted the International Financial Reporting Standards (IFRS) as a common accounting standard, each member state was required to have external enforcement bodies with responsibility for financial reporting supervision. This thesis investigates Sweden as a case study of how the evolvements initiated at the European level were set to practice in a member state. READ MORE

  5. 28. Computational Single-Cell Genomics Methods for Cell State Estimation and their Application to Hematopoietic Systems

    Author : Parashar Dhapola; Avdelningen för molekylär hematologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic Stem Cell; Single-Cell; Genomics; Epigenomics; transcriptomics; bioinformatics;

    Abstract : The focus of this doctoral dissertation was to develop novel and scalable computational genomics methods for analysing single-cell genomic modalities. Scarf, a highly memory-efficient single-cell data analysis toolkit, was developed to enable an analysis of very large-scale datasets on personal computers, and the execution of parallel workflows on server-scale computational systems. READ MORE

  6. 29. Computational modelling in systems biology: from rewriting cell fates to detecting tumours

    Author : Emil Andersson; Centrum för miljö- och klimatvetenskap (CEC); []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Beräkningsmodeller; Systembiologi; Genreguleringsnätverk; Cellomprogrammering; Energilandskap; iPSC; Agentbaserad modellering; T-cellsutveckling; Maskininlärning; Tumördiagnostik; Computational modelling; Systems biology; Gene regulatory network; Cell reprogramming; Energy landscape; iPSC; Agent-based modelling; Multi-scale modelling; T-cell development; Machine learning; Tumour diagnostics;

    Abstract : Computational modelling is becoming an increasingly important tool in biological research. By performing computer simulations of models, it becomes possible to test theories about a biological system against experimental data. Simulations can also be used as a replacement for experiments otherwise unattainable. READ MORE

  7. 30. Immunomodulation during human pregnancy : placental exosomes as vehicles of immune suppression

    Author : Ann-Christin Stenqvist; Lucia Mincheva-Nilsson; Maria Jenmalm; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; exosomes; microvesicles; pregnancy; placenta; syncytiotrophoblast; immune privilege; apoptosis; cytotoxicity; T regulatory cells; NKG2D; MICA B; FasL; TRAIL; immunologi; Immunology;

    Abstract : The mammalian pregnancy comprises a challenge to the maternal immune system since the fetus is semi-allogeneic and could thus be rejected. Pregnancy success is associated with the placenta that is not only essential for oxygen supply, nourishment and pregnancy hormones but also plays a role in the protection of the fetus against maternal immunologic attack. READ MORE