Search for dissertations about: "Related to cornea"

Showing result 1 - 5 of 10 swedish dissertations containing the words Related to cornea.

  2. 1. Aniridia-related keratopathy : structural changes, signaling pathways and clinical aspects

    Author : André Vicente; Fatima Pedrosa Domellöf; Berit Byström; Luis Abegão Pinto; Jing-Xia Liu; Anders Ivarsen; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aniridia; aniridia-related keratopathy; PAX6; keratoplasty; fetal cornea; Notch1; Wnt; sonic hedgehog; mTOR; keratocyte; oftalmiatrik; ophthalmology;

    Abstract : Aniridia is a congenital autosomal dominant, bilateral, panocular condition, caused by haploinsufficiency of the Pax6 transcription factor. Aniridia-related keratopathy (ARK) significantly affects vision and quality of life in these patients. READ MORE

  4. 2. Matrix metalloproteinases and their inhibitors in ocular neovascularization

    Author : Björn Steén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Angiogenesis; Neovascularization; Retina; Bruch membrane; Cornea; MMP; TIMP; VEGF; In situ hybridization.;

    Abstract : Growth of pathological new vessels (angiogenesis) in the eye is a leading cause of severe vision-loss. Ocular angiogenesis is seen in the anterior part of the eye as in corneal neovascularization, or in the posterior part as in diabetic retinopathy, retinopathy of prematurity or age-related macular degeneration. READ MORE

  5. 3. Inhibitors of corneal inflammation and angiogenesis : Prospectives and challenges

    Author : Pierfrancesco Mirabelli; Neil S Lagali; Beatrice Bourghardt Peebo; Francisco C Figueiredo; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Pathologic angiogenesis is involved in cancer and several blinding conditions such as wet age-related macular degeneration, proliferative retinopathies and corneal neovascularization.In these dieseases, the angiogenic triggers are hypoxia and inflammation, and both involve the main angiogenic mediator, which is Vascular Endothelial Growth Factor (VEGF). READ MORE

  6. 4. Angiogenesis modulates obesity and insulin sensitivity

    Author : Jennifer Honek; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Both white and brown fat are highly vascularized tissues and vascular functions in adipose tissues remain largely unknown. In this thesis work, we aimed to study blood vessels in modulation of adipose tissue functions under physiological conditions. READ MORE

  7. 5. Advanced surgeries, medicines and materials for corneal regeneration

    Author : Maria Xeroudaki; Neil Lagali; Beatrice Bourghardt Peebo; Per Fagerholm; Stefan Schrader; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Corneal transplantation is often the only treatment option in cases of corneal blindness, with the main challenges being the scarcity of human donors, risk for graft failure and suboptimal visual outcome due to suture-related issues. Alternative therapies are sought that either address the above transplantation issues directly or stimulate the cornea’s repair mechanism and regenerative properties to restore transparency without the need for transplantation. READ MORE