Search for dissertations about: "Renal volume"

Showing result 21 - 25 of 62 swedish dissertations containing the words Renal volume.

  2. 21. Longitudinal Models for Quantifying Disease and Therapeutic Response in Multiple Sclerosis

    Author : Ana M. Novakovic; Mats O. Karlsson; Etienne Pigeolet; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; NONMEM; multiple sclerosis; cladribine; EDSS; item response theory; relapse rate; absolute lymphocyte count; total volume T2 lesions; burden of disease; power; sample size; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Treatment of patients with multiple sclerosis (MS) and development of new therapies have been challenging due to the disease complexity and slow progression, and the limited sensitivity of available clinical outcomes. Modeling and simulation has become an increasingly important component in drug development and in post-marketing optimization of use of medication. READ MORE

  4. 22. The effect of anaesthesia and adrenergic therapy on the distribution and elimination of a crystalloid solution studied by volume kinetic analysis

    Author : Carl-Arne Ewaldsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Intravenous fluid therapy is a mandatory treasure during anaesthesia and surgery. It is sometimes combined with adrenergic therapy to maintain haemodynamic stability. It is of great importance to know how the body handles the distribution of fluid in these circumstances in order to minimize the risk of fluid overload. READ MORE

  5. 23. Fluid state and blood pressure control in patients on maintenance hemodialysis

    Author : Krassimir S Katzarski; Karolinska Institutet; Karolinska Institutet; []
    Keywords : chronic renal failure; hemodialysis; blood pressure; hypertension; fluid state; extracellular volume; blood volume; dry weight;

    Abstract : Cardiovascular disease is the main cause of high mortality in dialysis patients. Hypertension is a risk factor for cardiovascular disease and despite the use of highly efficient antihypertensive drugs (AHD), blood pressure (BP) is poorly controlled in the vast majority of hemodialysis (HD) patients. READ MORE

  6. 24. Nephrotic syndrome in children : functional, morphological and therapeutical aspects

    Author : Eva Löwenborg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Children; glomerular volume; glomerular filtration rate; effective renal plasma flow; rats; nephrotic syndrome; cyclosporine; nephrotoxicity;

    Abstract : Although cure rates of the idiopathic nephrotic syndrome in children have improved because of advances in immunosuppressive therapy, the pathogenesis and course of the disease remain controversial. We have followed children with nephrotic syndrome to study renal function and morphological changes in kidney biopsies and in an experimental study. READ MORE

  7. 25. Diabetic glomerulopathy-natural history, intervention and prediction of complications

    Author : Nina Perrin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Type 1 diabetes; adolescents; normoalbuminuria; normotension; glomerulopathy; kidney biopsy; ambulatory blood pressure measurement; kidney function tests; risk factors; microalbuminuria; hypertension;

    Abstract : Diabetes mellitus is one of the most common chronic diseases in childhood. Diabetic nephropathy (DN) is one of the threatening complications of diabetes that occurs in 30-40% of patients after 20 years duration of disease. READ MORE