Search for dissertations about: "Resistance polymorphism"

Showing result 1 - 5 of 64 swedish dissertations containing the words Resistance polymorphism.

  2. 1. Studies of tamoxifen resistance in breast cancer

    Author : Pia Palmebäck Wegman; Sten Wingren; Nils Wilking; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; tamoxifen; polymorphism; metabolic enzymes; oestrogen synthesis; Oncology; Onkologi;

    Abstract : Oestrogen is one of the most important hormonal regulators and is known to play a key role in the development and growth of breast cancer. The majority of tumours have a hormone dependent growth, and this is indicated by the presence of oestrogen receptors (ERs). READ MORE

  4. 2. Avian MHC: variation and selection in the wild

    Author : Helena Westerdahl; MEMEG; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; polymorphism; balancing selection; cDNA; avian malaria; great reed warbler; Djurekologi; bird; Animal ecology; immune defence; MHC class II; Major Histocompatibility Complex; MHC class I;

    Abstract : In vertebrates the Major Histocompatibility Complex (MHC) plays a central role in the specific immune defence against various pathogens. Compared with other coding genes the MHC genes exhibit an extremely high level of polymorphism that is maintained by balancing selection. READ MORE

  5. 3. Human glycogen synthase genes. Role in insulin resistance and hypoglycaemia

    Author : Marju Orho-Melander; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mutation; GYS2; GYS1; glycogen synthase; glycogen; insulin resistance; hypoglycaemia; liver glycogen synthase deficiency; glycogen storage disease type 0; Type 2 diabetes; metabolic syndrome; expression; chromosome 19; 19q13.3; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : Effective insulin-stimulated storage of excess glucose after a meal, and its rapid mobilisation in the fasting state provide basis of glucose homeostasis. Glycogen is the macromolecular storage form of glucose and glycogen synthase (GS) is the rate-limiting enzyme in glycogen synthesis. Skeletal muscle and liver are the major depots of glycogen. READ MORE

  6. 4. Fatty acid transport proteins : candidate genes for the insulin resistance syndrome

    Author : Karl Gertow; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Fatty acid transport protein; fatty acid; triglyceride; lipoprotein; obesity; insulin resistance; adipose tissue; polymorphism; association study; gene expression;

    Abstract : The insulin resistance syndrome is characterised by insulin resistance, obesity, hypertension, and a typical dyslipidaemia, predisposing to diabetes and cardiovascular disease. Metabolic disturbances of the insulin resistance syndrome include dysregulation of fatty acid (FA) homeostasis, for which adipose tissue serves a critical function. READ MORE

  7. 5. Studies on fat cell function in human obesity and insulin resistance

    Author : Patrik Löfgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Fat cell; lipolysis; lipogenesis; leptin; obesity; perilipin; polymorphism; post-obese; TNF-alpha; weightreduction.;

    Abstract : Enlarged fat cells, due to excess tri-glyceride (TG) stores with increased basal lipolysis (TG breakdown) and blunted action of the major regulatory hormones of fat cell metabolism (catecholamines and insulin) are hallmarks of common obesity in humans. It is, however, not known whether these aberrations are caused by obesity per se or is a consequence of obesity. READ MORE