Search for dissertations about: "Retinoblastoma Protein"

Showing result 1 - 5 of 26 swedish dissertations containing the words Retinoblastoma Protein.

  2. 1. Cell Cycle Regulation in Human Renal Cell Carcinoma

    Author : Ylva Hedberg; Göran Landberg; Börje Ljungberg; Göran Roos; Ulf Bergerheim; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Human Renal Cell Carcinoma; Cell Cycle; G1 S; Protein; Cyclin; p27; pRb; Phosphorylation; Tissue Microarray; Clinical Behaviour; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : ABSTRACTCell cycle regulation in human renal cell carcinomaYlva Hedberg, Departments of Medical Biosciences, Pathology, and Surgical andPerioperative Sciences, Urology Andrology, Umeå University, SwedenDeregulated growth control is a hallmark of neoplasia potentially caused by aberrant expression of cell cycle regulatory proteins. The importance of such aberrations in human renal cell carcinoma (RCC) has not been fully clarified. READ MORE

  4. 2. The gamma-tubulin meshwork as a therapeutic target

    Author : Lisa Lindström; Malmö Molekylär patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Gamma-tubulin; retinoblastoma; nuclear formation; meshwork; mitochondria; homeostasis;

    Abstract : Cancer is a heterogeneous disease and treatment regime is dependent on type and location of the tumor. Several of the commonly used chemotherapeutics target the functions of the microtubules. One of the major problems with these drugs is the adverse effects associated with their use. READ MORE

  5. 3. The use of protein biomarkers in ecotoxicology : Studies of oxidative and genotoxic stress in the blue mussel (Mytilus edulis)

    Author : Andreas Prevodnik; Michael Tedengren; Tomas Bollner; Kari Lehtonen; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; Biologi; Ecotoxicology; ekotoxikologi;

    Abstract : Many environmental pollutants, heavy metals and polyaromatic hydrocarbons (PAHs) among them, are toxic by oxidative stress. Oxidative stress may be defined as a state in an organism when its inherent capacity to handle oxyradicals is surpassed, and it may result in peroxidation of lipids, and damage to proteins and DNA. READ MORE

  6. 4. Functional characterization of the alternative reading frame protein p14ARF

    Author : Mikael Lindström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : p14ARF; p19ARF; alternative reading frame; CDKN2A; p53; B23; nucleophosmin; Burkitt´s lymphoma; nucleolus; senescence; Myc; E2F; phosphorylation; RNA interference; ribosome biogenesis;

    Abstract : A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears as a common theme in most malignant human tumors. READ MORE

  7. 5. On the role of the retinoblastoma tumor suppressor gene in hematopoietic differentiation

    Author : Gösta Bergh; Helsingborg Kliniska Vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antisense; leukemia; cell cycle; differentiation; hematopoiesis; p16; p53; tumor suppressor genes; RB; oligonucleotides; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

    Abstract : The aim of this study was to investigate the role of some tumor suppressor gene products (with emphasis on the retinoblastoma suppressor gene product) in the regulation of differentiation and proliferation in leukemic and normal hematopoietic cells. For this purpose, the expression of the tumor suppressor genes RB, p53 and p16 were artificially altered. READ MORE