Search for dissertations about: "Reverse transcriptase efficiency"

Showing result 1 - 5 of 6 swedish dissertations containing the words Reverse transcriptase efficiency.

  1. 1. Vaccination against drug-resistant HIV

    Author : Andreas Boberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; HIV; DNA vaccine; drug-resistance;

    Abstract : As the use of antiretroviral drug treatment increases worldwide, development of drug resistant HIV phenotypes is expected to increase. The frequency of drug- or multi-drug resistant virus transmitted in primary infections will consequently be more abundant. Logical vaccine targets in drug-resistant strains are reverse transcriptase and protease. READ MORE

  2. 2. In vivo bioluminescence imaging in preclinical trials of genetic vaccines

    Author : Stefan Petkov; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : DNA immunization is a rapidly developing vaccine platform for infectious diseases, cancer and allergies. The efficiency of DNA vaccination is largely determined by the efficiency of delivery and subsequent expression of genes encoding microbial and tumor antigens or allergens in the cells of vaccine recipients. READ MORE

  3. 3. iLocks: a novel tool for RNA assays with improved specificity

    Author : Tomasz Krzywkowski; Mats Nilsson; Gunnar von Heijne; Weng-Onn Lui; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; RNA; miRNA; non-coding RNA; padlock probes; rolling circle amplification; invader; single cell; in situ; adenovirus; virology; diagnostics; biokemi; Biochemistry;

    Abstract : The Central Dogma of molecular biology describes a framework for how genetic information is transferred in cells, placing RNA as a messenger between DNA and translated proteins. During the last years, interest in RNA research has grown tremendously due to the increasing understanding and recognition of the importance of RNA in regulation of gene expression, biochemical catalysis, and genome integrity surveillance. READ MORE

  4. 4. In vivo bioluminescence imaging in preclinical trials of genetic vaccines

    Author : Stefan Petkov; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : DNA immunization is a rapidly developing vaccine platform for cancer, infectious disease, and allergies. The efficiency of DNA vaccination is largely determined by the efficiency of delivery and subsequent expression of the HIV-1 genes in the cells. READ MORE

  5. 5. The effect of alpha-HGA on HIV-1 replication

    Author : Masoud Youssefi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; HIV-1; p24; capsid formation; alpha-HGA; antiretroviral; uptake;

    Abstract : Different classes of anti HIV-1 drugs are now available for treatment of HIV-1 infection. Although improved, these drugs show adverse effects and their long-term efficiency is severely hampered by the emergence of resistant viruses. Therefore, less toxic and more effective anti HIV-1 therapeutics agents are still needed. READ MORE