Search for dissertations about: "Rheumatoid Arthritis"

Showing result 1 - 5 of 407 swedish dissertations containing the words Rheumatoid Arthritis.

  1. 1. Modified Glycopeptides Targeting Rheumatoid Arthritis Exploring molecular interactions in class II MHC/glycopeptide/T-cell receptor complexes

    University dissertation from Umeå : Umeå universitet. Kemiska institutionen

    Author : Ida E. Andersson; Umeå universitet.; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Major histocompatibility complex; class II MHC; T-cell receptor; rheumatoid arthritis; collagen-induced arthritis; glycopeptide; amide bond isostere; comparative modeling; rational design; molecular docking; molecular dynamics simulation; statistical molecular design; NATURAL SCIENCES Chemistry Organic chemistry Bioorganic chemistry; NATURVETENSKAP Kemi Organisk kemi Bioorganisk kemi; organisk kemi; Organic Chemistry; Biorganic Chemistry; bioorganisk kemi; läkemedelskemi; läkemedelskemi;

    Abstract : Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that leads to degradation of cartilage and bone mainly in peripheral joints. In collagen-induced arthritis (CIA), a mouse model for RA, activation of autoimmune CD4+ T cells depends on a molecular recognition system where T-cell receptors (TCRs) recognize a complex between the class II MHC Aq protein and CII259-273, a glycopeptide epitope from type II collagen (CII). READ MORE

  2. 2. Juvenile chronic arthritis : a population based study on epidemiology, natural history and outcome

    University dissertation from Göteborg : Univ

    Author : Boel Andersson-Gäre; Högskolan i Jönköping.; [1994]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Arthritis; juvenile rheumatoid: epidemiology; Hyaluronic acid: blood; Rheumatoid factor: blood; Reumatiska sjukdomar; Barn; Doktorsavhandlingar; Rheumatic diseases; Children; Dissertations;

    Abstract : .... READ MORE

  3. 3. Collagen induced arthritis : pathogenetic mechanisms and relevance for rheumatoid arthritis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Rikard Holmdahl; Uppsala universitet.; [1985]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  4. 4. Pharmacometric Modeling in Rheumatoid Arthritis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Brigitte Lacroix; Uppsala universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; PKPD; immunogenicity; ACR; IPPSE; certolizumab pegol;

    Abstract : Biologic therapies have revolutionized the treatment of rheumatoid arthritis, a common chronic inflammatory disease, mainly characterized by the chronic inflammation of the joints. The activity and progression of the disease are highly variable, both between subjects and between the successive assessments for the same subject. READ MORE

  5. 5. Genetic markers in rheumatoid arthritis

    University dissertation from Umeå : Umeå universitet

    Author : Solbritt Rantapää Dahlqvist; Umeå universitet.; [1985]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; family history; genetic marker; HLA B27; HLA DR4; properdin factor B; C3 complement; -antitrypsin; haptoglobin; transferrin;

    Abstract : Genetic as well as environmental factors are believed to be of importance in the etiology of rheumatoid arthritis (RA). There are a number of previous studies of genetic markers in RA, but so far no genetic linkage and only a few associations have been found. Of the associations only one (with the HLA antigen DR4) appears to be well documented. READ MORE