Search for dissertations about: "Rho-family"

Showing result 1 - 5 of 16 swedish dissertations containing the word Rho-family.

  2. 1. The role of PKC in neuronal differentiation and in regulation of the actin cytoskeleton during neurite outgrowth

    Author : Ulrika Trollér; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytogenetics; Genetik; cytogenetik; Rho-family; actin cytoskeleton; neurite; differentiation; PKC; regulatory domain; Genetics;

    Abstract : Protein kinase C (PKC) is a family of serine/threonine kinases subgrouped into classical (α, βI, βII, γ), novel (δ, ε, η, θ) and atypical (ζ, ι/λ) isoforms. PKC can be activated by phorbol esters, and prolonged treatment of neuroblastoma cells has been shown to induce neuronal differentiation with neurite outgrowth and increased expression of neuronal genes. READ MORE

  4. 2. Defining the Role of GGTase-I in the Development of Rheumatoid Arthritis and Atherosclerosis

    Author : Omar M. Khan; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GGTase-I; Inflammation; RHO proteins; Rheumatoid Arthritis; Atherosclerosis;

    Abstract : RHO family proteins control cell movement and intracellular signaling by cycling between active GTP-bound and inactive GDP-bound states. Aberrant signaling of RHO GTPases has been implicated in many diseases including cancer and inflammation. READ MORE

  5. 3. Cytoskeletal Regulation During Embryonic Development in Drosophila melanogaster

    Author : Mojgan Padash; Udo Häckers grupp Utvecklingsbiologi i invertebrater; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Naturvetenskap; Natural science; DRhoGEF2; Actin cytoskeleton; Rho GTPase;

    Abstract : The development of multicellular organisms is associated with extensive rearrangements of cells and tissues. The driving force for these rearrangements is generated by the cell's actin cytoskeleton. During many morphogenetic processes dynamic rearrangement of the actin cytoskeleton is regulated by small GTPases of the Rho-family. READ MORE

  6. 4. The role of RhoD in actin dynamics, receptor trafficking and cancer cell migration

    Author : Vishal Nehru; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The Ras subfamily of Rho GTPases plays an important role in myriads of cell processes, such as actin cytoskeleton dynamics, membrane trafficking and cell migration. Additionally, they also participate in diverse signal transduction pathways that regulate gene transcription, cell survival and cell growth. READ MORE

  7. 5. ß2 integrin-induced signal transduction events in human neutrophils

    Author : Fredrik Melander; Malmö Experimentell patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammation; integrins; signal transduction; Rho GTPases; kinases; c-Cbl; General pathology; patologisk anatomi; pathological anatomy; Patologi allmän ; neutrophils;

    Abstract : Inflammation is a localized protective response in vascularized tissues and can be induced by microbial infection or cell and tissue injury. Polymorphonuclear neutrophils (PMN) are the most common white blood cells and are recognized as major cellular mediators of acute inflammation. READ MORE