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Showing result 1 - 5 of 46 swedish dissertations matching the above criteria.

  2. 1. Studies of two Yersinia proteins: YopJ, an inhibitor of inflammatory responses, and YpkA, a RhoA/Rac-binding kinase

    Author : Jean-Marie Dukuzumuremyi; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serologi; transplantation; serology; Immunology; CIB; AvrA; Yops; Rac; RhoA; YpkA; Yersinia; YopJ; Immunologi;

    Abstract : Eukaryotic cells possess sensitive systems for the detection of microbes and microbial-derived products. Bacteria-eukaryotic cells contact triggers several signaling pathways, most of which are dependent on protein-protein interactions followed by phosphorylation, leading to activation of defense mechanisms. READ MORE

  4. 2. Podocyte Melanocortin 1 Receptor Mediated Signaling : A potential new target for patients with kidney diseases

    Author : Johannes Elvin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Podocyte; Melanocortin 1 Receptor; actin cytoskeleton; nephrotic syndrome; adrenocorticotropic hormone; oxidative stress; RhoA; Kidney disease;

    Abstract : Treatment of patients with nephrotic syndrome (NS) is currently unspecific and directed at ameliorating the symptoms rather than eliminating the cause. NS is actually a multitude of glomerular diseases characterized by poorly understood disease mechanisms and symptoms that include proteinuria, hypoalbuminemia and edema. READ MORE

  5. 3. MicroRNA-Mediated Migration of Colon Cancer Cells

    Author : Anwar Algaber; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MicroRNA; Colon cancer; metastasis; HuR; RhoA; FHL2;

    Abstract : Colorectal cancer (CRC) is the second most common cancer in women and third most common cancer in men worldwide. The cause of the majority of death related to CRC is believed to be the migration of cancer cells to distant organs which is known as cancer metastasis. READ MORE

  6. 4. Cardioprotective mechanisms by inhibition of the HMG-CoA reductase pathway and stimulation of peroxisome proliferator-activated receptors in myocardial ischaemia-reperfusion

    Author : Aliaksandr Bulhak; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Endothelial function; endothelin-1; geranylgeranyl pyrophosphate; HMG-CoA reductase; infarct size; ischaemiareperfusion injury; myeloperoxidase; myocardium; nitric oxide; nitric oxide synthase; peroxisome proliferator-activated receptor-alpha; -gamma; PPAR-alpha; -gamma-ligands; RhoA; statins.;

    Abstract : Acute myocardial ischaemia causes metabolic changes and results in a rapid decrease in the energy available to the cell. This leads to cell injury that, depending on the length of the ischaemic time, is reversible or irreversible. READ MORE

  7. 5. The role of PKC in neuronal differentiation and in regulation of the actin cytoskeleton during neurite outgrowth

    Author : Ulrika Trollér; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytogenetics; Genetik; cytogenetik; Rho-family; actin cytoskeleton; neurite; differentiation; PKC; regulatory domain; Genetics;

    Abstract : Protein kinase C (PKC) is a family of serine/threonine kinases subgrouped into classical (α, βI, βII, γ), novel (δ, ε, η, θ) and atypical (ζ, ι/λ) isoforms. PKC can be activated by phorbol esters, and prolonged treatment of neuroblastoma cells has been shown to induce neuronal differentiation with neurite outgrowth and increased expression of neuronal genes. READ MORE