Search for dissertations about: "RhoA"

Showing result 11 - 15 of 46 swedish dissertations containing the word RhoA.

  2. 11. Defining the importance of protein geranylgeranylation in innate immunity

    Author : Murali K Akula; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAAX proteins; GGTase-I; RAC1; statins;

    Abstract : RHO family proteins and other intracellular proteins are prenylated with a 20-carbon lipid—a product of the cholesterol synthesis pathway—by protein geranylgeranyltransferase type I (GGTase-I). Prenylation is widely believed to target proteins to membranes where they encounter effector molecules that stimulate GTP-binding and activation. READ MORE

  4. 12. Cellular targets of Pseudomonas aeruginosa toxin Exoenzyme S

    Author : Maria Henriksson; Bengt Hallberg; Lars Rönnstrand; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Pseudomonas aeruginosa; ADP-ribosylation; GAP; Ras superfamily; NAD; ExoS; 14-3-3; Cellbiologi; Cell biology; Cellbiologi; molecular cell biology; molekylär cellbiologi;

    Abstract : Pseudomonas aeruginosa is an opportunistic pathogen that can cause life-threatening infections in immunocompromised patients. It uses a type III secretion dependent mechanism to translocate toxic effector proteins directly into the eukaryotic cell. READ MORE

  5. 13. Interplay between bacteria and host epithelial cells

    Author : Lisa Maudsdotter; Ann-Beth Jonsson; Cindy Grove Arvidson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Microbial-cell interaction; Adherence; Infection; Lactic acid bacteria; Antimicrobial peptides; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Bacterial pathogens have developed multiple ways of manipulating host cell functions to exploit the host environment. We found that interactions with epithelial cells increase the resistance of the human pathogen Neisseria meningitidis to the antimicrobial peptide LL-37. READ MORE

  6. 14. Making endothelial cells move : a study of angiomotin and binding partners

    Author : Nathalie Luna Persson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Angiogenesis is a process crucial for tumor growth and metastasis formation and encompasses the control of endothelial directional migration, anastomosis and lumen formation. We have previously shown that Angiomotin (Amot), a membrane-associated scaffold protein, plays an essential role in controlling endothelial cell migration and cellshape. READ MORE

  7. 15. The multifunctional GAP protein YopE of Yersinia is involved in effector translocation control and virulence

    Author : Elin Isaksson; Hans Wolf-Watz; Joseph Barbieri; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yersinia; T3SS; YopE; GAP activity; translocation control; virulence; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : The Gram-negative bacterium Yersinia pseudotuberculosis employs a type 3 secretion system (T3SS) to establish infections. The T3SS translocates a diverse set of effector proteins directly into the host cells. READ MORE