Search for dissertations about: "RhoA"
Showing result 16 - 20 of 46 swedish dissertations containing the word RhoA.
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16. RhoGTPase Signaling in Cell Polarity and Gene Regulation
Abstract : RhoGTPases are proteins working as molecular switches as they bind and hydrolyze GTP. They are in their active conformation when GTP is bound and are then able to interact with their effector proteins, which relay the downstream signaling. When the GTP is hydrolyzed to GDP, the RhoGTPase is inactivated. READ MORE
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17. Characterization of novel glomerular proteins : role in physiology and disease
Abstract : Glomerular damage accounts for the majority of chronic kidney disease cases, the prevalence of which is dramatically escalating worldwide, mainly due to increase in diabetes and associated nephropathy. The costs for treatment of CKD represent an enormous burden to the health care system. READ MORE
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18. Microenvironmental control of malignant growth
Abstract : The tumor microenvironment (TME) comprises a complex milieu of different cell types, including cancer associated fibroblasts (CAFs) and immune cells, blood vessels, and the extracellular matrix. Through its interaction with cancer cells, it plays an essential role in cancer invasion and metastasis. READ MORE
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19. Mitigating neuroinflammation : new potential therapeutics and targets
Abstract : Neurodegenerative disorders, from chronic diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) to more acute injuries such traumatic brain injury (TBI), present a particular challenge to public health as they lack treatments and have devastating consequences. Across the variety of central nervous system (CNS) diseases and injuries, inflammation is a hallmark and potential target for effective therapies. READ MORE
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20. Defining the Role of GGTase-I in the Development of Rheumatoid Arthritis and Atherosclerosis
Abstract : RHO family proteins control cell movement and intracellular signaling by cycling between active GTP-bound and inactive GDP-bound states. Aberrant signaling of RHO GTPases has been implicated in many diseases including cancer and inflammation. READ MORE