Search for dissertations about: "RhoA"

Showing result 6 - 10 of 46 swedish dissertations containing the word RhoA.

  2. 6. Mechanisms of stretch-induced growth and contractile differentiation in vascular smooth muscle

    Author : Asad Zeidan; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Fysiologi; Physiology; SM22a; ERK1 2; caveolae; stretch; Smooth muscle; differentiation;

    Abstract : Vascular smooth muscle can adapt to increased intraluminal pressure by remodelling and hypertrophy, as seen in hypertension. The molecular mechanisms responsible for this are still incompletely characterized. READ MORE

  4. 7. Cellular responses to the DNA damaging cytolethal distending toxin

    Author : Lina Guerra; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cytolethal distending toxin (CDT) is a genotoxin, which belongs to a group of bacterial protein toxins called cyclomodulins. These are characterized by their interference with the eukaryotic cell cycle. CDT causes DNA damage, which induces cell cycle arrest and apoptosis. READ MORE

  5. 8. Tumor microenvironment : the paradoxical action of fibroblasts

    Author : Twana Alkasalias; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The term tumor refers to an abnormal and pathological tissue characterized by a massive cell growth; it comprises various populations of transformed and malignant cells. These cells cross-communicate with each other and with different types of cells in the surrounding microenvironment. READ MORE

  6. 9. Role of YopE and LcrH in effector translocation, HeLa cell cytotoxicity and virulence

    Author : Margareta Aili; Roland Rosqvist; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yersinia pseudotuberculosis; bacterial pathogenesis; YopE; LcrH; virulence; effector translocation; type III secretion; regulation; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : In order to establish an extra-cellular infection the gram-negative bacteria Yersinia pseudotuberculosis uses a type III secretion system (T3SS) to translocate a set of anti-host effectors into eukaryotic cells. The toxins disrupt signalling pathways important for phagocytosis, cytokine production and cell survival. READ MORE

  7. 10. Towards a Refined Model of Neutrophil Motility

    Author : Vesa-Matti Loitto; Karl-Eric Magnusson; Tommy Andersson; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human polymorphonuclear leukocytes. PMNL; neutrophils; neutrophil motility; N-formyl-Met-Leu-Phe; Medical microbiology; Medicinsk mikrobiologi;

    Abstract : The ability of human polymorphonuclear leukocytes (PMNL; neutrophils), to sense and move to sites of infection is essential for our defense against pathogens. Cell motility is critically dependent on a dynamic remodeling of morphology. READ MORE