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Showing result 1 - 5 of 6 swedish dissertations matching the above criteria.
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1. RhoGTPase Signaling in Cell Polarity and Gene Regulation
Abstract : RhoGTPases are proteins working as molecular switches as they bind and hydrolyze GTP. They are in their active conformation when GTP is bound and are then able to interact with their effector proteins, which relay the downstream signaling. When the GTP is hydrolyzed to GDP, the RhoGTPase is inactivated. READ MORE
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2. Roles of mammalian Scribble in polarity signaling, virus offense and cell-fate determination
Abstract : Mammalian Scribble is a target for proteins encoded by human papilloma virus, retro- and flaviviruses. Tick-borne encephalitis virus (TBEV) is a flavivirus that have evolved distinct strategies to escape antiviral responses. READ MORE
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3. A Podocyte view on RhoGTPases and actin cytoskeleton regulation
Abstract : Proteinuria is a hallmark symptom of chronic kidney disease, that if left to persist constitutes a risk for progression of disease. Symptomatic treatment aiming at decreasing proteinuria is therefore standard practice. READ MORE
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4. Germinal centers : why and why not? The humoral response in primary immunodeficiency
Abstract : An efficient and regulated immune system is required for protection against pathogens. B cells are required for a humoral response. For a sustained humoral response against pathogens germinal center (GC) reactions are required. In the GC reaction, B cells with antigen-specific B cell receptors are selected and expanded. READ MORE
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5. Role of Wnt-5a in breast cancer
Abstract : Breast cancer is one of the most common cancer forms in the industrialized world. Only in Sweden, nearly 6000 women are diagnosed with breast cancer each year and 1/3 of them eventually succumb to the disease. READ MORE