Search for dissertations about: "Ribonucleotide Reductase"

Showing result 1 - 5 of 77 swedish dissertations containing the words Ribonucleotide Reductase.

  2. 1. Herpes simplex ribonucleotide reductase

    Author : Rolf Ingemarson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Ribonucleotide reductase; herpes simplex virus;

    Abstract : In all bacterial, plant and animal cells, as well as in many viruses, genetic information resides in DNA (deoxyribonucleic acid). Replication of DNA is essential for proliferation, and DNA-containing viruses (such as herpesviruses) must carry out this process within the mammalian cells they infect. READ MORE

  4. 2. Ribonucleotide reductase and DNA damage

    Author : Pelle Håkansson; Lars Thelander; Claes Gustafsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ribonucleotide reductase; DNA damage; dNTP pools; Medical cell biology; Medicinsk cellbiologi;

    Abstract : A prerequisite for a multicellular organism to survive is the ability to correctly replicate and repair DNA while minimizing the number of heritable mutations. To achieve this, cells need a balanced supply of deoxyribonucleoside triphosphates (dNTPs), the precursors for DNA synthesis. READ MORE

  5. 3. High (valent) on O2 : Ribonucleotide Reductase and Methane Monooxygenase

    Author : Juliane John; Martin Högbom; Pål Stenmark; Peter Moody; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ribonucleotide Reductase; Methane Monooxygenase; biokemi; Biochemistry;

    Abstract : Macromolecular X-ray crystallography (MX) is a powerful method to investigate protein structures. However, proteins with redox-active centres and radicals are very susceptible to photoreduction. READ MORE

  6. 4. Allosteric Regulation and Radical Transfer in Ribonucleotide Reductase

    Author : Karl-Magnus Larsson; Pär Nordlund; Derek Logan; Roger Kornberg; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allosteric regulation; substrate specificity; ribonucleotide reductase; radical; Biochemistry; Biokemi;

    Abstract : The stability of biological life over time requires that the integrity of the genetic material of an organism, the genome, be maintained as it is passed on from one generation to the next. All known cellular life has DNA-based genomes, which are duplicated before each cell division in a process called replication. READ MORE

  7. 5. Class I Ribonucleotide Reductases : overall activity regulation, oligomerization, and drug targeting

    Author : Venkateswara Rao Jonna; Anders Hofer; Arne Holmgren; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ribonucleotide reductase; GEMMA; Allosteric regulation; medicinsk biokemi; Medical Biochemistry;

    Abstract : Ribonucleotide reductase (RNR) is a key enzyme in the de novo biosynthesis and homeostatic maintenance of all four DNA building blocks by being able to make deoxyribonucleotides from the corresponding ribonucleotides. It is important for the cell to control the production of a balanced supply of the dNTPs to minimize misincorporations in DNA. READ MORE