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Showing result 1 - 5 of 12 swedish dissertations matching the above criteria.

  2. 1. Class I Ribonucleotide Reductases : overall activity regulation, oligomerization, and drug targeting

    Author : Venkateswara Rao Jonna; Anders Hofer; Arne Holmgren; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ribonucleotide reductase; GEMMA; Allosteric regulation; medicinsk biokemi; Medical Biochemistry;

    Abstract : Ribonucleotide reductase (RNR) is a key enzyme in the de novo biosynthesis and homeostatic maintenance of all four DNA building blocks by being able to make deoxyribonucleotides from the corresponding ribonucleotides. It is important for the cell to control the production of a balanced supply of the dNTPs to minimize misincorporations in DNA. READ MORE

  4. 2. The evolution of ribonucleotide reductases

    Author : Daniel Lundin; Anthony Poole; Britt-Marie Sjöberg; Christos Ouzounis; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Evolution; ribonucleotide reductase; horizontal gene transfer; phylogeny; protein classification; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Abstract : Ribonucleotide reductase (RNR) catalyses the transformation of RNA building blocks, ribonucleotides, to DNA building blocks, deoxyribonucleotides. This is the only extant reaction pathway for de novo synthesis of DNA building blocks and the enzyme is thus necessary for life. RNR is found in all but a few organisms. READ MORE

  5. 3. Activation and inhibition of diiron and iron-manganese ribonucleotide reductases

    Author : Ana Popović-Bijelić; Astrid Gräslund; Anders Hofer; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; class Ic; C. trachomatis; cytotoxicity; KP772; lanthanum; manganese–iron cofactor; metal complex; oligopeptide inhibitor; ribonucleotide reductase; Triapine; tyrosyl radical; Biophysics; biofysik;

    Abstract : Ribonucleotide reductase (RNR) catalyses the reduction of ribonucleotides to deoxyribonucleotides. In conventional class I RNRs the active site is located in the R1 subunit, and the R2 subunit contains a diiron cofactor and a stable tyrosyl radical essential for activity. READ MORE

  6. 4. Structural and functional studies on ribonucleotide reductase protein B2 from Escherichia coli

    Author : Margareta Karlsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ribonucleotide reductases; Eshcerichia coli;

    Abstract : Ribonucleotide reductase catalyzes the reduction of ribonucleotidesto the corresponding deoxyribonucleotides, the building blocks forDNA. The enzyme from Escherichia coli consists of two proteins.Bl and B2. Protein B2 contains two dinuclear iron centers and astable tyrosyl radical. READ MORE

  7. 5. Quaternary structure and interaction approaches to allosteric regulation of class I ribonucleotide reductases

    Author : Mikael Crona; Britt-Marie Sjöberg; Mark Meuth; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ribonucleotide reductase; allosteric regulation; quaternary structure; subunit interactions; enzyme activity; SPR; GEMMA; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Abstract : Deoxyribonucleic acid (DNA) chains in which our genetic blueprint is stored are built from four DNA precursors by DNA polymerases. The enzyme ribonucleotide reductase (RNR) provides the only de novo synthesis pathway of deoxyribonucleotides from ribonucleotides and is essential for nearly all organisms. READ MORE