Search for dissertations about: "Ribonucleotides"

Showing result 1 - 5 of 23 swedish dissertations containing the word Ribonucleotides.

  2. 1. Ribonucleotides in DNA - Application in genome-wide DNA polymerase tracking and physiological role in eukaryotes

    Author : Katrin Kreisel; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ribonucleotides; DNA instability; DNA polymerase eta; nuclear DNA; mitochondrial DNA;

    Abstract : The genetic code in the eukaryotic cell is stored in the form of DNA, which is more resistant to hydrolysis than RNA. Replication fidelity and DNA repair mechanisms are in place to ensure genomic integrity to preserve the information encoded. READ MORE

  4. 2. Pathogenic mechanisms affecting mitochondrial DNA replication and transcription

    Author : Meenakshi Singh; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mtDNA; ribonucleotides; nucleoside analogues; POLRMT;

    Abstract : Mitochondria are cytoplasmic organelles fundamental to life and health. In mitochondria, energy from the food we eat is converted into adenosine triphosphate (ATP), which in turn is used as a source of chemical energy to drive a multitude of cellular reactions. READ MORE

  5. 3. The consequences of DNA lesions for mitochondrial DNA maintenance

    Author : Josefin M. E. Forslund; Sjoerd Wanrooij; Nasim Sabouri; Erik Johansson; Claes Gustafsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mitochondrial DNA; DNA replication; DNA lesions; DNA polymerase γ; ribonucleotide incorporation; medicinsk biokemi; Medical Biochemistry;

    Abstract : Eukaryotic cells have their own energy-producing organelles called mitochondria. The energy is stored in the adenosine triphosphate (ATP) molecule and is produced via the oxidative phosphorylation process inside the mitochondria. Thirteen of the essential proteins required for this process are encoded on the mitochondrial DNA (mtDNA). READ MORE

  6. 4. Quaternary structure and interaction approaches to allosteric regulation of class I ribonucleotide reductases

    Author : Mikael Crona; Britt-Marie Sjöberg; Mark Meuth; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ribonucleotide reductase; allosteric regulation; quaternary structure; subunit interactions; enzyme activity; SPR; GEMMA; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Abstract : Deoxyribonucleic acid (DNA) chains in which our genetic blueprint is stored are built from four DNA precursors by DNA polymerases. The enzyme ribonucleotide reductase (RNR) provides the only de novo synthesis pathway of deoxyribonucleotides from ribonucleotides and is essential for nearly all organisms. READ MORE

  7. 5. The evolution of ribonucleotide reductases

    Author : Daniel Lundin; Anthony Poole; Britt-Marie Sjöberg; Christos Ouzounis; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Evolution; ribonucleotide reductase; horizontal gene transfer; phylogeny; protein classification; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Abstract : Ribonucleotide reductase (RNR) catalyses the transformation of RNA building blocks, ribonucleotides, to DNA building blocks, deoxyribonucleotides. This is the only extant reaction pathway for de novo synthesis of DNA building blocks and the enzyme is thus necessary for life. RNR is found in all but a few organisms. READ MORE