Search for dissertations about: "Roger Johansson"

Showing result 11 - 15 of 16 swedish dissertations containing the words Roger Johansson.

  2. 11. Human mononuclear phagocytes : Production of reactive oxygen species generated by the NADPH oxidase

    Author : Agneta Johansson; Roger Sundler; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Human professional phagocytes constitute the first line of defence against invading microorganisms. With a membrane-bound enzyme system, the NADPH oxidase, these cells generate bactericidal metabolites. Activation of NADPH oxidase results in a generation of reactive oxygen species, e.g. READ MORE

  4. 12. Profilin:actin in cell motility : A search for profilin:actin binding proteins

    Author : Thomas Johansson; Roger Karlsson; Björn Öbrink; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; profilin; actin; Cell biology; Cellbiologi;

    Abstract : The profilin:actin complex is a major source of actin for actin filament growth in vivo. A number of proteins regulating either profilin or actin has been described since profilin:actin was isolated during the 1970s. Since then, profilin and actin and their binding partners have been intensively studied. READ MORE

  5. 13. Cisplatin-resistance and cell death in malignant pleural mesothelioma cells

    Author : Veronica Janson; Kjell Grankvist; Roger Henriksson; Parviz Behnam-Motlagh; Anders Johansson; Boris Zhivotovsky; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; BH3-only proteins; caspase; cell morphology; potassium transport; protein kinase B PKB Akt ; signalling pathways; time; Clinical chemistry; Klinisk kemi;

    Abstract : Malignant pleural mesothelioma (MPM) is an aggressive, treatment-resistant tumour. Cisplatin (cis-diamminedichloroplatinum (II)) is the best single-agent chemotherapy for MPM, but platinum-based combination therapies give the best overall response rates. However, cisplatin use is limited by resistance and severe side effects. READ MORE

  6. 14. The expression and molecular functions of LRIG proteins in cancer and psoriasis

    Author : Terese Karlsson; Håkan Hedman; Mikael Johansson; Roger Henriksson; Kim Jensen; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LRIG1; LRIG2; LRIG3; LMO7 lung cancer; glioma; psoriasis; Oncology; onkologi;

    Abstract : The leucine-rich repeats and immunoglobulin-like domains (LRIG) family consists of three integral membrane proteins that are important in human cancer. LRIG1 is a negative regulator of growth factor signaling. Its expression is associated with longer survival in several cancer types, and the gene has been shown to function as a tumor suppressor. READ MORE

  7. 15. Experimental therapies of malignant glioma : with emphasis on angiogenesis inhibition

    Author : Maria Sandström; Roger Henriksson; Mikael Johansson; Anja Smits; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; angiogenesis; VEGF; tyrosinekinaseinhibitor; ZD6474; plasminogenactivator; tPA; uPA; proteomics; Oncology; Onkologi;

    Abstract : Malignant glioma consists of a group of diseases where the localisation and the nature of the disease makes treatment an extreme challenge. Two important biological features of malignant glioma cells are their infiltrative growth and their ability to induce angiogenesis. READ MORE