Search for dissertations about: "Rolf Nygren"
Showing result 1 - 5 of 8 swedish dissertations containing the words Rolf Nygren.
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1. The Negotiable Child : The ILO Child Labour Campaign 1919-1973
Abstract : This dissertation examines the Conventions and Recommendations to regulate the minimum age for admission to employment between the years 1919 and 1973 – the ILO minimum age campaign. The adoption process has been studied in its chronological and historical context. READ MORE
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2. Preclinical Development of New Alkylating Oligopeptides for Cancer Therapy
Abstract : Oligopeptides can be used to carry cytotoxic agents in cancer chemotherapy, using tumour-associated proteins as the molecular target for selectivity. During the seventies and eighties Peptichemio, a cocktail of six alkylating oligopeptides carrying m-L-sarcolysin, was investigated in a wide variety of human malignancies. READ MORE
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3. New preclinical strategies for characterization and development of anticancer drugs
Abstract : Increased understanding of the molecular mechanisms underlying cancer development has shifted drug discovery towards target driven drug development the last decades, but the development of effective cancer drugs has been hampered by the lack of predictive preclinical models. 3-D cultures, considered to more accurately reflect solid tumors in vivo, have been proposed as one way to increase the predictability of clinical efficacy in cancer drug discovery and development. READ MORE
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4. Cellular Pharmacology of the Novel Antitumoural Cyanoguanidine CHS 828
Abstract : The antitumoural cyanoguanidine CHS 828 has shown promising activity in a number of preclinical and clinical studies. However, the mechanisms underlying the cell death induced by CHS 828 has not been clarified. This thesis describes in vitro studies of the cellular pharmacology of CHS 828. READ MORE
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5. New Methods to Screen for Cancer Drugs and to Evaluate their Mechanism of Action
Abstract : Cancer is a common disease and due to problems with resistance against cancer drugs and the limited benefit from chemotherapy in many diagnoses, there is a need to develop new cancer drugs. In this thesis new methods to screen for cancer drugs and to evaluate their mechanism of action are discussed. READ MORE