Search for dissertations about: "Rolf Nygren"

Showing result 6 - 8 of 8 swedish dissertations containing the words Rolf Nygren.

  2. 6. High-throughput screening using multicellular tumor spheroids to reveal and exploit tumor-specific vulnerabilities

    Author : Wojciech Senkowski; Mårten Fryknäs; Rolf Larsson; Peter Nygren; Mats Gustafsson; Krister Wennerberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; spheroids; high-throughput screening; nitazoxanide; OXPHOS; gene expression profiling; statins; drug repositioning; 3D cell culture; quiescent cells; Medical Science; Medicinsk vetenskap;

    Abstract : High-throughput drug screening (HTS) in live cells is often a vital part of the preclinical anticancer drug discovery process. So far, two-dimensional (2D) monolayer cell cultures have been the most prevalent model in HTS endeavors. However, 2D cell cultures often fail to recapitulate the complex microenvironments of in vivo tumors. READ MORE

  4. 7. Exploring Cancer Drugs In Vitro and In Vivo : With Special Reference to Chemosensitivity Testing and Early Clinical Development

    Author : Anne von Heideman; Peter Nygren; Bengt Tholander; Rolf Larsson; Seija Grénman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytotoxic drug; in vitro assay; drug development; phase I clinical trial; Oncology; Onkologi; Oncology; Onkologi;

    Abstract : The aims of this thesis were to investigate the utility of in vitro drug sensitivity testing to optimize the use of cancer chemotherapy and to assess the properties of a new cancer drug in a phase I clinical trial. Tumour cells from patients were analysed with the short-term Fluorometric Microculture Cytotoxicity Assay (FMCA). READ MORE

  5. 8. Future Technology Support of Command and Control : Assessing the impact of assumed future technologies on cooperative command and control

    Author : Mats Persson; Else Nygren; Tim Grant; Uppsala universitet; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; command; control; cooperative; collaboration; decision-making; effectiveness; human-computer interaction; microworld; network-centric; military; team; beslutsfattande; effektivitet; ledning; mikrovärld; militär; människa-datorinteraktion; nätverkscentrerad; samarbete; team; Datavetenskap med inriktning mot människa-datorinteraktion; Computer Science with specialization in Human-Computer Interaction;

    Abstract : In response to technological advances, especially in the field of information and communication technology (ICT), the so called revolution in military affairs (RMA) and later the concept of network-centric warfare (NCW) emerged as a theory to further utilize technology for military command and control (C2). Advocates of the Swedish ROLF 2010-vision and the concept of NCW have made claims and assumptions that future technology will improve mission effectiveness by, for example, increasing the understanding of a current situation and its development, the speed of command, and providing means to utilize more efficient forms of organizations. READ MORE