Search for dissertations about: "Roman A. Zubarev"
Found 5 swedish dissertations containing the words Roman A. Zubarev.
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1. Characterization of Polypeptides by Tandem Mass Spectrometry Using Complementary Fragmentation Techniques
Abstract : In the growing field of proteomics identification of proteins by tandem mass spectrometry (MS/MS) is performed by matching experimental mass spectra against calculated spectra of all possible peptides in a protein database. One problem with this approach is the false-positive identifications. READ MORE
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2. Mass spectrometry of biopolymers based on ion-induced desorption
Abstract : Various aspects of biopolymer molecular characterization by their molecular masses havebeen studied, with emphasis on ion-induced desorption and time-of-flight mass Spectrometry(TOF MS). Limitations of the average-isotopic mass concept, as well as the utility ofaccurate monoisotopic mass measurements for deriving amino-acid and elementalcompositions, are discussed. READ MORE
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3. New Proteomics Methods and Fundamental Aspects of Peptide Fragmentation
Abstract : The combination of collision-activated dissociation, (CAD) and electron capture dissociation, (ECD) yielded a 125% increase in protein identification. The S-score was developed for measuring the information content in MS/MS spectra. This measure made it possible to single out good quality spectra that were not identified by a search engine. READ MORE
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4. Secondary and Higher Order Structural Characterization of Peptides and Proteins by Mass Spectrometry
Abstract : The work in this thesis has demonstrated the advantages and limitations of using MS based technologies in protein and peptide structural studies. Tandem MS, specifically electron capture dissociation (ECD) have shown the ability to provide structural insights in molecules containing the slightest of all modifications (D-AA substitution). READ MORE
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5. Multiplexed absolute quantification of blood plasma proteins using targeted proteomics
Abstract : Proteins are the molecular building blocks of all living organisms. They are the functioning actors in metabolism and communication, and they give specific architecture and purpose to all tissues. Their abundance is dynamic and can be interpreted and associated to different physiological states or diseases. READ MORE