Search for dissertations about: "Ryanodine 1 Receptor"

Showing result 1 - 5 of 10 swedish dissertations containing the words Ryanodine 1 Receptor.

  2. 1. Anaesthesia and Genetics of the Ryanodine 1 Receptor

    Author : Marcus Ewert Broman; Lund Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; General Anaesthesia; Ryanodine 1 Receptor; Malignant Hyperthermia; Genetics;

    Abstract : The only validated method to characterize the phenotype and to reach a definitive diagnosis of Malignant Hyperthermia Susceptibility (MHS; OMIM *145600), a pharmacogenetic disease linked to the Ryanodine 1 receptor gene (RYR1; OMIM *180901), is an invasive muscle contraction test requiring a muscle biopsy, according to the European (IVCT) protocol or to the North American (CHCT) protocol. The series of scientific papers in this thesis tries to reach as far as possible in diagnosing MHS from peripheral venous blood samples collected at the patients’ local primary care provider and sent to the laboratory over significant transportation time and distance. READ MORE

  4. 2. Receptor-operated signaling pathways in normal and diabetic pancreatic islet cell function

    Author : Fan Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Loss of glucose-dependent insulin release is an early pathogenetic event in human type 2 diabetes. Impaired glucose-mediated insulin secretion from pancreatic islet β-cells leads to insulin deficiency and thus hyperglycemia. READ MORE

  5. 3. Cell death and signal transduction pathways in Alzheimer's disease : the role of presenilin 1

    Author : Bogdan O Popescu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mutated presenilins (PSs) may cause familial Alzheimer's disease (FAD) by altering neuronal signal transduction pathways, by increasing AP production or by triggering a number of proapoptotic mechanisms. The present thesis explores mechanisms by which PSs regulate signal transduction and cell death with relevance to AD. READ MORE

  6. 4. Roles of the transient receptor potential channels and the intracellular Ca2+ channels in Ca2+ signaling in the beta-cells

    Author : Amanda Jabin Fågelskiöld; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Ca2 signaling;

    Abstract : Previous studies from our group reported that pancreatic β-cells express ryanodine receptors (RyRs) that can mediate Ca2+-induced Ca2+ release (CICR). The full consequences of the activation of RyRs on Ca2+ signaling in these cells, however, remained unclear. READ MORE

  7. 5. Dynamics of Ca2 handling in vascular smooth muscle

    Author : Karl Dreja; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; smooth muscle; phenotypic modulation; caveolae; Physiology; confocal microscopy; calcium; Fysiologi;

    Abstract : Intracellular Ca2+ is a key regulator of vascular contractility, and thereby of blood perfusion and pressure. Ca2+ signals are essential also for cell migration, proliferation and regulation of numerous enzymes. READ MORE