Search for dissertations about: "Sören Lehmann"

Found 5 swedish dissertations containing the words Sören Lehmann.

2. 1. In vitro studies of retinoids and arsenic in non-M3 acute myeloid leukemia

   Author : Sören Lehmann; Karolinska Institutet; Karolinska Institutet; Sweden Stockholm Huddinge University Hospital Department of Medicine; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Despite advances in the treatment of patients with acute myeloid leukemia (AML), the majority of the patients will die from their disease. The current intensive therapy for AML is also complicated my substantial morbidity and mortality and, as a result, many patients cannot be given the most effective therapy. READ MORE

4. 2. Population-based studies in Myelodysplastic syndromes : Prognostic scores, socioeconomic status, and therapy-related disease

   Author : Daniel Moreno Berggren; Elisabeth Ejerblad; Sören Lehmann; Martin Jädersten; David Bowen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Myelodysplastic syndromes; Chronic myelomonocytic leukaemia; Prognostication; Comorbidity; Therapy-related disease; Real-world data; Population-based studies; Medicinsk vetenskap; Medical Science;

   Abstract : The aim of this thesis was to expand the epidemiological knowledge of the haematological malignancy MDS and the related condition chronic myelomonocytic leukaemia (CMML). Using nationwide registers, the papers in this thesis address aspects of prognostication, comorbidity, socioeconomic status, and therapy-related disease, using a population-based approach. READ MORE

5. 3. Identification and Functional Significance of Aberrant Long Non-coding RNAs in Acute Myeloid Leukemia : Biological and Prognostic Implications

   Author : Anne H. Neddermeyer; Sören Lehmann; Jonas Larsson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute myeloid leukemia AML ; hematopoiesis; long non-coding RNAs lncRNAs ; RNA- and CAGE-sequencing; CRISPRi; CRISPR-Cas9; NEAT1; APL; NPM1; IDH2; all-trans retinoic acid; arsenic trioxide; venetoclax; drug resistance and sensitivity; prognosis; RADICL-sequencing; Molekylär medicin; Molecular Medicine;

   Abstract : Acute myeloid leukemia (AML) is the most frequently diagnosed type of acute leukemia in adults. It commonly affects people aged 60 or older, as incidence increases with age, and it is characterized by the accumulation of immature hematopoietic progenitor cells in the bone marrow. READ MORE

6. 4. Molecular genetic studies on Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia - with focus on prognostic markers

   Author : Kerstin Willander; Peter Söderkvist; Mats Linderholm; Kourosh Lotfi; Sören Lehmann; Linköpings universitet; []
   Keywords : ;

   Abstract : The present thesis is focused on the prognostic value of genetic variations and alterations in the initiation and development of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) patients. Several prognostic markers based on genetic or chromosomal aberrations are today used in clinic in these heterogeneous diseases. READ MORE

7. 5. Improving prognostication and treatment choices for patients with AML

   Author : Albin Österroos; Sören Lehmann; Marc H G P Raaijmakers; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukaemia; Acute promyelocytic leukaemia; Prognostication; Personalised medicine; Risk stratification; Real-world data; Next-generation sequencing; Azacitidine; Venetoclax; Medicinsk vetenskap; Medical Science;

   Abstract : The treatment landscape of the aggressive haematological malignancy acute myeloid leukaemia (AML) has expanded but the prognosis is still unsatisfactory poor. Here, we aimed at improving prognostication and treatment choices in AML by addressing current clinical obstacles to successful AML treatment. READ MORE