Search for dissertations about: "S-adenosyl-L-methionine"

Found 5 swedish dissertations containing the word S-adenosyl-L-methionine.

  2. 1. Modeling of methyl transfer reactions in S-Adenosyl-L-Methionine dependent enzymes

    Author : Polina Velichkova; Fahmi Himo; Margareta Blomberg; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Theoretical chemistry; Teoretisk kemi;

    Abstract : A very important trend for studying biomolecules is computational chemistry. In particular, nowadays it is possible to use theoretical methods to figure out the catalytic mechanism of enzyme reactions. READ MORE

  4. 2. Enzymatic mechanisms in biotin synthesis : vitamin B6 catalysis and phosphoryl transfer

    Author : Jenny Sandmark; Karolinska Institutet; Karolinska Institutet; []
    Keywords : X-ray crystallography; biotin biosynthesis; pyridoxal-5 -phosphate; aminotransferase; aluminium fluoride; S-adenosyl-L-methionine; 7; 8-diaminopelargonic acid synthase; dethiobiotin synthetase; biotin; phosphoryl transfer; amiclenomycin.;

    Abstract : With the large number of pathogenic bacteria that have developed antibiotic resistance it is increasingly important to find new targets for antibiotics. Our interest in the biotin biosynthesis pathway originates from this drug design perspective. All organisms require biotin, but it is only synthesised in bacteria, in plants and in some fungi. READ MORE

  5. 3. Quantum Chemical Modeling of Enzymatic Methyl Transfer Reactions

    Author : Polina Georgieva; Fahmi Himo; Nino Russo; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; reaction mechanism; Theoretical chemistry; Teoretisk kemi;

    Abstract : In this thesis, quantum chemistry, in particular the B3LYP density functional method, is used to investigate a number of methyl transfer enzymes. Quantum chemical methodology is today a very important tool in the elucidation of properties and reaction mechanisms of enzyme active sites. READ MORE

  6. 4. Targeting Infectious Disease : Structural and functional studies of proteins from two RNA viruses and Mycobacterium tuberculosis

    Author : Anna M. Jansson; T. Alwyn Jones; Sherry L. Mowbray; E. Yvonne Jones; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; RNA virus; coronavirus; alphacoronavirus; nsp1; TGEV; flavivirus; Modoc virus; NS5; methyltransferase; mRNA capping; Mycobacterium tuberculosis; tuberculosis; 1-deoxy-D-xylulose 5-phosphate reductoisomerase; DXR; fosmidomycin analogues; MEP pathway; drug development; xray-crystallography; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biokemi; Biochemistry; Medicinal Chemistry; Läkemedelskemi;

    Abstract : The recent emergence of a number of new viral diseases as well as the re-emergence of tuberculosis (TB), indicate an urgent need for new drugs against viral and bacterial infections.Coronavirus nsp1 has been shown to induce suppression of host gene expression and interfere with host immune response. READ MORE

  7. 5. Mechanisms of apoptosis in secretory and neuronal cells : role of oxidative stress and calcium overload

    Author : Maria Ankarcrona; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Apoptosis is a widespread physiological mechanism to regulate tissue homeostasis both during development and in adult organs. However, the cell deletion program can be inappropriately activated or suppressed under pathological conditions. READ MORE