Search for dissertations about: "S-nitrosoglutathione"

Found 4 swedish dissertations containing the word S-nitrosoglutathione.

2. 1. Towards Pharmacological Treatment of Cystic Fibrosis

   Author : Charlotte Andersson; Aleksander Edelman; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; cystic fibrosis; airway epithelium; genotype; CFTR; chloride transport; genistein; phenotype; phenylbutyrate; S-nitrosoglutathione; Cellbiologi; Cell biology; Cellbiologi; entomologi; Entomology;

   Abstract : S-nitrosogluthatione is an endogenous substance, present at decreased levels in the lungs of CF patients and was recently found to induce mature CFTR in airway epithelial CF cell lines. We show that S-nitrosoglutathione in physiological concentrations increases the presence of ΔF508 CFTR in the cell membrane and induces cAMP dependent chloride transport in cystic fibrosis airway epithelial cells. READ MORE

4. 2. Functional Aspects of Epithelia in Cystic Fibrosis and Asthma

   Author : Zhanna Servetnyk; Godfried Roomans; Michael Wilschansky; Uppsala universitet; []
   Keywords : Cell biology; cystic fibrosis; CFTR; chloride transport; airway epithelium; sweat gland; asthma; corticosteroids; montelukast; Cellbiologi;

   Abstract : The cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP activated chloride channel in the apical membrane of epithelial cells, is defective in patients with cystic fibrosis (CF). Research efforts are focused on chloride channel function in order to find a cure for the disease. READ MORE

5. 3. Gene expression in buccal keratinocytes with emphasis on carbonyl metabolism

   Author : Claudia A Staab; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The inner lining of the cheek, the buccal mucosa, is a target for air-borne, dietary and tobacco usage-derived carcinogens, but also interesting from a drug delivery point of view. Cancer arising in the buccal epithelium, buccal squamous cell carcinoma (BSCC), often diagnosed at a late disease stage, is highly aggressive and recurrent, emphasizing the need for novel approaches in diagnosis and therapy. READ MORE

6. 4. Effects of nitric oxide on hemostasis with special attention to platelet function

   Author : Johanna Albert; Karolinska Institutet; Karolinska Institutet; []
   Keywords : nitric oxide; bleeding time; platelet aggregation; platelet secretion; P-selectin expression; flow cytometry; NG-monomethyl-L-arginine; L-NMMA; nasal air; skin perfusion; GSNO; humans;

   Abstract : Endogenous endothelium-derived NO provides a continuous vasodilating effect, but may also in humans have an antithrombotic effect, which is exerted by inhibition of platelet function and by vasodilatation. Inhalation of NO selectively relaxes the pulmonary vascular bed, without causing systemic hypotension. READ MORE