Search for dissertations about: "S-nitrosylation"

Showing result 1 - 5 of 6 swedish dissertations containing the word S-nitrosylation.

  2. 1. Characterization and Crystallization of Anchorless Glypican-1

    Author : Gabriel Svensson Birkedal; Glykobiologigruppen; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; S-nitrosylation; nitric oxide; protein stability; protein conformation; X-ray crystallography; calorimetry; spectroscopy; proteoglycan; glypican; heparan sulfate;

    Abstract : Glypicans are cell-surface heparan sulfate proteoglycans that regulate Wnt, Hedgehog, bone morphogenetic protein, and fibroblast growth factor signaling through their heparan sulfate chains. Recent studies have shown that glypican core proteins also have functional roles in growth factor signaling, but biochemical and structural knowledge regarding the core proteins is limited. READ MORE

  4. 2. Regulation of human thioredoxin and glutaredoxin systems by oxidation and S-nitrosylation

    Author : Seyed Isaac Hashemy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The homeostasis of intracellular redox status has a crucial role in the cell survival and different processes such as DNA synthesis, gene expression, enzymatic activity, etc. This homeostasis is achieved via an intense balance between pro-oxidants and anti-oxidants. READ MORE

  5. 3. Islet constitutive nitric oxide synthase and nitric oxide production. Modulatory effects on insulin and glucagon secretion

    Author : Björn Åkesson; Allmänmedicin och klinisk epidemiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; Pharmacological sciences; mouse; carbachol; muscarinic agonist; cyclic nucleotides; calcium-fluxes; NOS-inhibitors; in vitro and in vivo; insulin and glucagon secretion; Nitric oxide NO ; constitutive nitric oxide synthase cNOS ; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : The aim of this thesis was to elucidate the role of nitric oxide (NO) in the transduction signalling of insulin and glucagon release by stimulating or inhibiting islet endogenous NO-production as well as by using NO donors. Insulin release stimulated by L-arginine, the substrate for constitutive NO-synthase (cNOS)-catalyzed NO-production, was increased by the selective NOS-inhibitor NG-nitro-L-arginine methyl ester (L-NAME) and suppressed by the intracellular NO donor hydroxylamine. READ MORE

  6. 4. Deciphering microglia plasticity in glioma

    Author : Dalel Saidi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can contribute to contrasting effects by either proinflammatory, anti-inflammatory, or tumor-supportive phenotypes. READ MORE

  7. 5. Studies on microglia in tumor biology and neurobiology

    Author : Xianli Shen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Microglia are innate immune cells that reside in the central nervous system (CNS). Their activities are critical for ensuring the correct microenvironment for brain development and for maintaining homeostasis in the brain after birth. READ MORE