Search for dissertations about: "S. Fransson"

Showing result 1 - 5 of 19 swedish dissertations containing the words S. Fransson.

2. 1. Discovery of Small Peptides and Peptidomimetics Targeting the Substance P 1-7 Binding Site : Focus on Design, Synthesis, Structure-Activity Relationships and Drug-Like Properties

   Author : Rebecca Fransson; Anja Sandström; John S Svendsen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; substance P 1-7; peptidomimetics; structure-activity relationship; drug-like properties; phenylalanine; imidazole; MAP aryl amides; carbonylation; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; Läkemedelskemi;

   Abstract : Biologically active peptides are important for many physiological functions in the human body and therefore serve as interesting starting points in drug discovery processes. In this work the neuropeptide substance P 1–7 (SP1–7, H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH), which has been demonstrated to reduce neuropathic pain and attenuate opioid withdrawal symptoms in animal models, has been addressed in a medicinal chemistry program with the overall aim of transforming this bioactive peptide into more drug-like compounds. READ MORE

4. 2. Analysis and development of strategies for magnetic resonance functional neuroimaging

   Author : Peter Fransson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : neuroimaging; human brain; functional activation; magnetic resonance imaging; cerebral blood oxygenation;

   Abstract : This thesis focuses on strategies for oxygenation-sensitive MRI that are designed to measure alterations in brain physiology induced by changes in neuronal activity. In a first study, it was shown that the temporal evolution of BOLD MRI signal changes in response to both brief and sustained visual activation are equally well visible in FLASH and EPI recordings. READ MORE

5. 3. Thermal ice pressure on structures in ice covers

   Author : Lennart Fransson; Luleå tekniska universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Structural Engineering; Konstruktionsteknik;

   Abstract : A method to estimate thermal ice pressure is proposed. Temperature-history and stress-history in a confined ice sheet heated at the surface is illustrated with numerical examples. Material parameters for columnar lake ice has been evaluated from classical laboratory experiments and a field program presented here. READ MORE

6. 4. Prevention and intervention therapies in auditory trauma

   Author : Anette Fransson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Hearing impairment is one of the most common health conditions in developed countries. It is estimated that approximately 70 million people worldwide are deaf. For patients with a severe to profound hearing loss a cochlear implant (CI) is the only treatment today. READ MORE

7. 5. Prediction of power and energy use in dwellings : Addressing apects of thermal mass and occupant behaviour

   Author : Victor Fransson; Avdelningen för Installations- och klimatiseringslära; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Byggnadssimulering; Termisk massa; Värmetröghet; boendes beteende; hushållsel; varmvatten; building simulation; thermal mass; thermal inertia; occupant behaviour; household electricity; domestic hot water;

   Abstract : Households are responsible for approximately 26 % of the annual energy use in the EU. Following the EU-directives regarding energy performance in buildings, international initiatives have been taken in Europe to help countries to define and include guidelines in their own building codes, for example, to establish the concept of zero energy buildings, ZEBs. READ MORE