Search for dissertations about: "S. elegans"

Showing result 6 - 10 of 13 swedish dissertations containing the words S. elegans.

2. 6. Structural Studies of Polyamine Biosynthesis Enzymes: Potential Targets for Drugs against Tropical Parasites

   Author : Veronica Tamu Dufe; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; inhibitors; protein crystallography; Molecular biophysics; Molekylär biofysik; tropical parasites; polyamine biosynthesis enzymes;

   Abstract : Two enzymes involved in the biosynthesis of polyamines, ornithine decarboxylase (ODC, from human and Leishmania donovani) and spermidine synthase (SPDS, from Plasmodium falciparum and Caenorhabditis elegans) were studied using biochemical methods, homology modelling and X-ray crystallography. ODC catalyses the first and committed step in polyamine biosynthesis, the decarboxylation of ornithine to putrescine. READ MORE

4. 7. Identification and Characterization of Novel Candidate Oncogenes

   Author : Marina Mencinger; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk genetik; Clinical genetics; RBP56; APRIL; TFG; FUS; EWS; EST database; fusion genes; chromosome; molecular genetics; cancer; Cytology; oncology; cancerology; Cytologi; onkologi;

   Abstract : Using computer-assisted sequence homology searches we identified three genes encoding proteins similar to certain fusion partner proteins in cancer. The novel APRIL gene was localized to 15q25 and encodes a protein, containing an acidic amino-acid region similar to that/those of leukemia-associated fusion partner proteins DEK and SET. READ MORE

5. 8. Transcriptome Analyses of the Nematode-trapping Fungus Monacrosporium haptotylum

   Author : Margareta Tholander; Biologiska institutionen; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; Biologi; Microbiology; bacteriology; virology; mycology; Pathogenic fungi; Nematophagous fungi; Nematodes; Biological control; cDNA microarray; Transcriptome analysis; Nematode-trapping fungi; Mikrobiologi; bakteriologi; virologi; mykologi;

   Abstract : Nematode-trapping fungi are soil living organisms with the ability to infect and kill nematodes. These fungi have developed specialized infection structures, traps for the capture of nematodes. To be able to identify genes in nematode-trapping fungi that are involved in the infection of nematodes cDNA microarrays were constructed. READ MORE

6. 9. A Genetic Survey of the Pathogenic Parasite Trypanosoma cruzi

   Author : Anh-Nhi Tran; Lena Åslund; John Kelly; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Trypanosoma cruzi; Chagas ; gene discovery; EST; sequencing; DGC3; repeats; gene family; CL Brener; trypanothione synthetase; TcTRS locus; alleles; polymorphism; RNA-binding protein; TcPTB; stage-specific expression; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

   Abstract : Trypanosoma cruzi, the causative agent of Chagas´ disease, is an evolutionarily ancient species with distinct biological and immunological characteristics. A fundamental understanding of the basic biology of the parasite is necessary in order to develop reliable therapeutic and prophylactic agents against T. cruzi. We have, as a part of the T. READ MORE

7. 10. Characterization of candidate disease genes from human chromosomes 11g13 and 22q

   Author : Darek Kedra; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Fugu rubripes; 11q13 region; MEN1; menin; GCK; DMPKL; meningioma; clathrin; adaptin; NIPSNAP; synaptogyrin; TOM1; SMARCB1;

   Abstract : Two regions of the human genome, 11q13 and 22q, have been shown to harbor numerous disease-related genes, among them tumor suppressor genes (TSGs). The aim of this project was to construct transcription maps within these chromosomal segments, and thus provide a basis for further analysis of some of the genes for their involvement in disease-related processes. READ MORE