Search for dissertations about: "S100B"

Showing result 21 - 25 of 31 swedish dissertations containing the word S100B.

2. 21. Post-Cardiac Arrest Care : Therapeutic Hypothermia, Patient Outcomes and Relatives’ Experiences

   Author : Ing-Marie Larsson; Sten Rubertsson; Marja-Leena Kristofferzon; Jo Kramer-Johansen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cardiac arrest; therapeutic hypothermia; prognostication; outcome; quality of life; relatives; Medicinsk vetenskap; Medical Science;

   Abstract : The overall aim of the thesis was to study post-resuscitation care of cardiac arrest (CA) patients with a focus on therapeutic hypothermia treatment, outcomes up to six months post-CA and relatives’ experiences during the hospital stay.In Paper I, the aim was to asses effectiveness of hypothermia treatment with cold, 4°C, intravenous crystalloid infusion combined with ice packs. READ MORE

4. 22. Protein complexes : assembly, structure and function

   Author : Kristina Wilhelm; Ludmilla Ludmilla Morozova-Roche; Catharina Svanborg; Umeå universitet; []
   Keywords : HAMLET; ELOA; lysozyme; amyloid; medicinsk biokemi; Medical Biochemistry;

   Abstract :  Most proteins must fold into their native conformations to fulfil their biological functions. Failure of proteins to fold leads to cell pathology and a broad range of human diseases referred to as protein misfolding disease, e.g., Alzheimer’s disease, Parkinson’s disease, and type II diabetes. READ MORE

5. 23. Pharmacological and genetic modulation of adult neurogenesis in animal models relevant to neuropsychiatric disorders

   Author : Martin Thor Egeland; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : During the past decade, the modulation of adult neurogenesis has been an intensively studied area of neuroscience due to the implications for understanding of physiological mechanisms in the adult brain and the potential clinical applications for neuropsychiatric disorders. This research has resulted in countless discoveries during a relatively short period of time elucidating mechanistic details about where adult neurogenesis takes place, how the process of neurogenesis occurs and how this process can be regulated at several different steps by, not only endogenous mechanisms which normally maintain a homeostasis of adult neurogenesis, but also by exogenous regulation using genetic and pharmacological modulations to manipulate steps of the process. READ MORE

6. 24. Interplay between blood-brain barrier disruption and neuroinflammation following severe traumatic brain injury

   Author : Caroline Lindblad; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : A severe traumatic brain injury (TBI) holds deleterious consequences for the afflicted, its next-of-kin and society. Still today, prognosis is semi-desolate. One explanation for this might be pathophysiological processes ensuing the primary trauma that are but indirectly targeted for treatment. READ MORE

7. 25. Studies of in vivo prostate amyloidosis and autoimmune responses towards amyloid structures in neurodegeneration

   Author : Kiran Yanamandra; Ludmilla Morozova-Roche; Dina Raveh; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; amyloidosis; immune reactivity; S100A8 A9; insulin; α-synuclein; Biochemistry; Biokemi; medicinsk biokemi; Medical Biochemistry;

   Abstract : By using multidisciplinary analysis of CA inclusions in prostate glands of patients diagnosed with prostate cancer, we have revealed that their major components are the amyloid forms of S100A8 and S100A9 proteins associated with numerous inflammatory conditions and types of cancer. We have demonstrated that material closely resembling CA can be produced from S100A8/A9 in vitro and shows the characters of amyloids. READ MORE