Search for dissertations about: "SCF"

Showing result 1 - 5 of 46 swedish dissertations containing the word SCF.

  2. 1. Molecular Studies of Mast Cell Migration and Apoptosis : Two Ways of Regulating Mast Cell Numbers at Sites of Inflammation

    Author : Jessica Alfredsson; Gunnar Nilsson; Hans-Uwe Simon; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; mast cell; SCF; IL-3; FcεRI; migration; apoptosis; Bim; Bcl-2; Bcl-XL; Akt; FOXO; MAPK; Patologi; Pathology; Patologi;

    Abstract : Upon activation mast cells release numerous proinflammatory mediators. With this feature, mast cells play an important role in host defense against pathogens, and are involved in tissue remodeling and wound healing. However, in cases of excessive inflammation the effects of mast cells are detrimental. READ MORE

  4. 2. Regulation of Mast Cell Survival

    Author : Christine Möller; Gunnar Nilsson; Alf Grandien; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; mast cell; A1; Bfl-1; Bim; Bcl-2 family members; basophil; SCF; forkhead; survival; Patologi; Pathology; Patologi;

    Abstract : Mast cells are long-lived effector cells of importance for both acute and chronic inflammations. Mast cells can be activated in many different ways, leading to the release of inflammatory mediators. In contrast to most other inflammatory cells, activated mast cells have the capacity to recover, regranulate and thereby be activated again. READ MORE

  5. 3. Signal Transduction in Mast Cell Migration

    Author : Magnus Sundström; Bengt Hallberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; HMC-1; Kit; MAP kinase; mast cells; mastocytosis; p38; SCF; TGF-β; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : Mast cells are essential effector cells in the immune system as they release several inflammatory mediators. An accumulation of mast cells has been described in inflammatory conditions such as asthma and allergic rhinitis. READ MORE

  6. 4. Neural Stem Cell Differentiation and Migration

    Author : Anna Erlandsson; Karin Forsberg-Nilsson; Bengt Westermark; Christer Betsholtz; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; CNS; stem cells; neuron; PDGF; SCF; differentiation; migration; ERK; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Medicinsk biokemi; Medical Biochemistry;

    Abstract : Neural stem cells are the precursors of neurons, astrocytes and oligodendrocytes. During neural development, the division of stem cells takes place close to the lumen of the neural tube, after which they migrate to their final positions within the central nervous system (CNS). READ MORE

  7. 5. Neural Stem and Progenitor Cells : Cellular Responses to Known and Novel Factors

    Author : Jimmy Larsson; Karin Forsberg-Nilsson; Ola Hermanson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neural stem cell; differentiation; proliferation; migration; PDGF; SCF; NRBP2; medulloblastoma; Biochemistry; Biokemi; Medical Biochemistry; Medicinsk biokemi;

    Abstract : Neural stem cell self-renewal and differentiation are tightly regulated events during CNS development, leading to cell division into new neural stem cells or the formation of neurons and glial cells. This thesis focuses on the cellular responses induced by known and novel factors in neural stem and progenitor cells (NSPCs). READ MORE