Search for dissertations about: "SCH-23390"

Found 5 swedish dissertations containing the word SCH-23390.

  2. 1. Morphological and Physiological Adaptations in Cichlid Crystalline Lenses

    Author : Marcus Schartau; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; SKF-38393; D1-agonist; optical properties 6-hydroxydopamine; optical measurements; organ culture; dopamine; teleost; lens circulation; Lens; SCH-23390; melatonin; multifocal optical system;

    Abstract : Vertebrate eyes share a common ancestry as well as the basic design with a pupil, a retina and a lens. The lens is essential for perceiving the details in the world around us and ensures that a sharp image of the surroundings is focused onto the photoreceptors in the retina. READ MORE

  4. 2. Effects of nicotine on mesolimbocortical dopaminergic neurotransmission : a pharmacological study in the rat

    Author : Magnus Nisell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : nicotine; dopamine; ventral tegmental area; accumbens; prefrontal cortex; c-fos; drug-dependence; sensitization; mecamylamine; D; receptors; SCH 23390;

    Abstract : Tobacco-smoking represents a form of drug addiction to nicotine (NlC) and the reinforcing and dependence-producing properties of NIC depend largely on central dopamine (DA) neurons, located in the ventral tegmental area (VTA) and projecting mainly to the nucleus accumbens (NAc; mesolimbic DA system) and the medial prefrontal cortex (PFC; mesocortical DA system). Generally, the mesolimbic DA system plays a pivotal role in the reinforcing effects of natural rewards as well as of drugs of abuse. READ MORE

  5. 3. Food availability, physical activity and body weight : role of dopamine, neuropeptide Y and orexin

    Author : Ricard Nergårdh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : During the last decades our knowledge about neuroendocrine control of energy balance has increased tremendously. Numerous neuropeptides and hormones with pronounced effects on feeding and body weight have been identified and put into schemes as anorexic or orexigenic signals. READ MORE

  6. 4. PET studies on the mechanisms of action of antidepressant and antipsychotic drugs

    Author : Kai-Chun Yang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Positron emission tomography (PET) is a non-invasive molecular imaging technique suitable for examination of neurochemical biomarkers in the living brain. Among these applications, PET studies are used to facilitate the development of novel psychotropic drugs. READ MORE

  7. 5. Novel mechanism of action of antipsychotic drugs : effects on neuropeptides in rat brain

    Author : Susanne H M Gruber; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Schizophrenia; D-amphetamine; Antipsychotic drugs; Neurotensin; Neuropeptide Y; Rat brain; Microdialysis;

    Abstract : Schizophrenic patients have been reported to have lower concentrations of neurotensin (NT)-like immunoreactivity (-LI) in their cerebrospinal fluid (CSF) that normalize after treatment with antipsychotic drugs. Schizophrenic patients also had higher CSF concentrations of neuropeptide Y (NPY)-LI compared to controls, thus involvement of NPY in the disease has also been suggested. READ MORE