Search for dissertations about: "SELDI-TOF MS"

Showing result 6 - 10 of 11 swedish dissertations containing the words SELDI-TOF MS.

  2. 6. Disturbed Islet Function and Alterations in Islet Protein Expression

    Author : Henrik Ortsäter; Peter Bergsten; Franz Schuit; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell biology; islet; glucose; oleate; corticosterone; oxygen tension; insulin release; protein profiling; Clark-like electrodes; SELDI-TOF MS; PPI-B; 11β-HSD1; Cellbiologi; Cell biology; Cellbiologi;

    Abstract : Pancreatic β-cells sense the concentration of glucose in the systemic circulation through metabolism of the sugar molecule. Failure to correlate the blood sugar concentration to an appropriate metabolic signal disrupts the function of the β-cell as a controller of glucose homeostasis and may contribute to the development of type 2 diabetes mellitus. READ MORE

  4. 7. In search of diagnostic and prognostic markers for thyroid cancer : a proteomics approach

    Author : Anastasios Sofiadis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Thyroid tumors; thyroid proteomics; S100A6; MIB-1; 2DE; MALDI-TOF-MS; SELDI-TOF-MS; protein pre-fractionation;

    Abstract : Early diagnosis of cancer can influence the therapeutic strategy increasing the chances of cure or, at least, prolonged survival. It is equally important to be able to detect prognostic signs, i.e. tumor features that characterize its behavior. READ MORE

  5. 8. Multivariate analyses of proteomic and metabolomic patterns in brain tumors

    Author : Carl Wibom; A Tommy Bergenheim; Henrik Antti; Mikael Johansson; Janne Lehtiö; Umeå universitet; []
    Keywords : glioblastoma; meningioma; proteomics; metabolomics; multivariate analyses; onkologi; Oncology;

    Abstract : Glioblastoma multiforme (GBM) is the most common primary brain tumor. Given the current standard of care, the prognosis for patients diagnosed with this disease is still poor. There consequently exists a need to improve current treatments, as well as to develop new ones. READ MORE

  6. 9. Cancer proteomics : method development for mass spectrometry based analysis of clinical materials

    Author : Maria Pernemalm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : To improve cancer treatment, biomarkers for diagnostics and therapeutic guidance are desperately needed. Mass spectrometry (MS) based proteomics is one of the most promising methods for biomarker discovery. Clinical materials such as blood and tumor tissue provide an excellent starting material for biomarker discovery studies. READ MORE

  7. 10. Molecular aspects of post-Chornobyl and sporadic papillary thyroid carcinoma

    Author : Andrii Dinets; Karolinska Institutet; Karolinska Institutet; []
    Keywords : papillary thyroid carcinoma;

    Abstract : Papillary thyroid carcinoma (PTC) exhibits various molecular abnormalities, both when sporadic and radiation-related. PTC is still diagnosed in adult individuals who were younger than 18 years at the time of the Chornobyl accident in 1986 and lived within the contaminated area. READ MORE