Search for dissertations about: "SFRP2"

Found 4 swedish dissertations containing the word SFRP2.

  2. 1. Intratumoral heterogeneity in glioblastoma: subtype transition and cell-to-cell communication

    Author : Min Guo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : glioblastoma; intratumoral heterogeneity; subtype transition; intercellular communication; U-343; SOX2; SFRP2; PROX1; THRAP3; TGFBI; NOTCH1; and ADAMTS1;

    Abstract : Glioblastoma is a most aggressive brain tumor with a median overall survival of less than two years. The current treatment is surgery, chemotherapy, and radiotherapy. However, glioblastoma is difficult to treat and recurs some time after treatment. READ MORE

  4. 2. Regulation of midbrain dopaminergic neuron development by Wnts, sFRPs and bHLH proteins

    Author : Julianna M V Kele-Olovsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Parkinson’s disease (PD) is a chronic neurodegenerative disorder. The main pathology is characterized by progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra leading to loss of striatal dopamine innervation. The knowledge about the fundamental mechanisms behind the degenerative process has been limited. READ MORE

  5. 3. Wnts in development : focus on midbrain

    Author : Emma Rakel Andersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Studies in the field of embryonic development reveal the temporal and spatial requirement of specific genes/proteins in the formation of a given tissue. The specific knowledge of which genes/proteins regulate development of the ventral midbrain (VM) provides a guideline for the in vitro differentiation of specific cell types therein, such as dopaminergic (DA) neurons. READ MORE

  6. 4. New Insights in Genetic and Epigenetic Mechanisms Involved in Parathyroid Tumorigenesis

    Author : Lee Starker; Peyman Björklund; Barbra Miller; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parathyroid; yumorigenesis; mutation; exome sequencing;

    Abstract : Primary hyperparathyroidism (pHPT) is a pathology associated with one or multiple hyperfunctioning parathyroid glands.  The disease prevalence occurs in roughly 1-2% of the population primarily post-menopausal women.  The molecular pathology of the disease is poorly understood. READ MORE