Search for dissertations about: "SH-SY5Y cells"

Showing result 16 - 20 of 49 swedish dissertations containing the words SH-SY5Y cells.

  2. 16. Expression and regulation of steroid metabolizing enzymes in cells of the nervous and skeletal systems : Special focus on vitamin D metabolism

    Author : Mokhtar Almokhtar; Maria Norlin; Kjell Wikvall; Gösta Eggertsen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Little is known about the mechanisms of vitamin D actions in the brain and bone. In this study, the metabolism of vitamin D and its regulation in various cell cultures of the nervous and skeletal systems were examined. READ MORE

  4. 17. Distribution and function of nicotinic acetylcholine receptors in glia cells and neurons with focus on the neuroprotective mechanisms of cholesterol lowering drugs in Alzheimer's disease

    Author : Jin Xiu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Nicotinic acetylcholine receptor; Alzheimer s disease; glia cells; Abeta; cholesterol; cholesterollowering drugs;

    Abstract : Nicotinic acetylcholine receptors (nAChRs) are involved in the regulation of many processes including synapses regeneration, neurotransmission and neuroprotection in the central nervous system (CNS). There is increasing evidence for the disturbances in nAChRs in Alzheimer's disease (AD). READ MORE

  5. 18. Cell interactions in the CNS and their consequences for neuronal apoptosis

    Author : Mikaela Berglund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Aggregate cultures; apoptosis; automated image analysis; cytochrome c; interactions; JNK; microglia; neuron; neural precursor cells; rotenone; UV.;

    Abstract : The central nervous system consists of an intricate network of neurons and glial cells that depend on reciprocal communication to develop and maintain the vital functions of the brain. if the balance is disturbed by injury or disease, two cell types in particular, microglia and astrocytes, respond by producing factors that help combat the infection or delimit the affected area. READ MORE

  6. 19. Investigation on Pre- and Postsynaptic Ca2+ Signaling in Neuronal Model Systems

    Author : Jelena Krjukova; Åkerman Karl; Kukkonen Jyrki; Rydqvist Bo; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; calcium; neurotransmitter release; nicotine; depolarization; G-protein coupled receptor; muscarinic; phospholipase C; m-3M3FBS; Fysiologi; Physiology; Fysiologi;

    Abstract : Communication between neuronal and non-neuronal is called volume transmission when the released neurotransmitter (NT) acts via diffusion and affects several target cells. Both the neurosecretory and postsynaptic cell responses are linked to [Ca2+]i elevations. READ MORE

  7. 20. Polyamine analogues inhibit neuroblastoma cell growth

    Author : Erika Söderstjerna; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; survivin; cell cycle; polyamine analogue; polyamines; apoptosis; neuroblastoma; MYCN;

    Abstract : Abstract Neuroblastoma is a highly malignant neoplasm found in children. Although children with high-risk neuroblastoma respond to chemotherapy, relapses are common and an estimated long-time survival prognosis is approximately 15%. Thus, there is a tremendous need for new chemotherapeutic drugs for the treatment for neuroblastoma. READ MORE