Search for dissertations about: "SH-SY5Y cells"

Showing result 21 - 25 of 49 swedish dissertations containing the words SH-SY5Y cells.

  2. 21. In vitro modelling of tau phosphorylating kinases : emphasis of Cdk5

    Author : Anne Jämsä; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The main hallmarks of Alzheimer’s disease (AD) are extracellular deposits of betaamyloid (Aβ) and intracellular neurofibrillary tangles (NFT) composed of highly phosphorylated tau protein. Abnormal hyperphosphorylation of tau is the most deleterious step in NFT formation making the use of kinase inhibitors an attractive treatment possibility in AD. READ MORE

  4. 22. Cell death and signal transduction pathways in Alzheimer's disease : the role of presenilin 1

    Author : Bogdan O Popescu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mutated presenilins (PSs) may cause familial Alzheimer's disease (FAD) by altering neuronal signal transduction pathways, by increasing AP production or by triggering a number of proapoptotic mechanisms. The present thesis explores mechanisms by which PSs regulate signal transduction and cell death with relevance to AD. READ MORE

  5. 23. Age dependent beta-amyloid isoforms and implications of different drug treatments as studied in different transgenic mouse models and cell lines

    Author : Tamanna Mustafiz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The Amyloid-β (Aβ) peptide is the main component of the the amyloid plaques in Alzheimer’s Disease (AD) and has been implicated to be the cause of the disease. During the last decade it has become increasingly evident that soluble, oligomeric forms of Aβ are more toxic to neurons than the plaques and might play an important role in the disease pathogenesis. READ MORE

  6. 24. Steroids and steroid-metabolizing enzymes in the nervous system : Special focus on cell survival and sex hormone synthesis

    Author : Ida Emanuelsson; Maria Norlin; Kjell Wikvall; Lena Ekström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biokemi; Biochemistry;

    Abstract : Some steroids in the brain and peripheral nervous system have been shown to have neuroprotective effects but the knowledge is limited. The present study examines the effects of steroids including oxysterols, vitamin D and vitamin D analogs on cell viability/growth and steroidogenesis in the nervous system. READ MORE

  7. 25. Evaluation of neurotoxic properties of gliotoxin

    Author : Viktoria Axelsson; Anna Forsby; Marion Ehrich; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mycotoxin; gliotoxin; A. fumigatus; cytotoxicity; neurotoxicity; Neurochemistry; Neurokemi;

    Abstract : The occurrence of mould in food and animal feed is a severe problem due to the secondary metabolites, called mycotoxins, which can possess toxic activity. Aspergillus fumigatus is a common fungus found in improperly stored animal feed and the abundance of spores of the fungus is frequently spread into the air. READ MORE