Search for dissertations about: "SH2"
Showing result 1 - 5 of 30 swedish dissertations containing the word SH2.
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1. Quantum Chemical Studies of Radical Cation Rearrangement, Radical Carbonylation, and Homolytic Substitution Reactions
Abstract : Quantum chemical calculations have been performed to investigate radical cation rearrangement, radical carbonylation, and homolytic substitution reactions of organic molecules. The rearrangement of the bicyclopropylidiene radical cation to the tetramethyleneethane radical cation is predicted to proceed with stepwise disrotatory opening of the two rings. READ MORE
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2. Molecular biology of Brouton's tyrosine kinase
Abstract : X-linked agammaglobulinemia (XLA) is caused by an arrest in the B lymphocyte differentiation. XLA patients lack mature B-cells and subsequently antibody production. The defective gene causing XLA is the BTK gene, which codes for the protein Bruton s tyrosine kinase (Btk), a cytoplasmic enzyme related to the Src family of kinases. READ MORE
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3. Characterization and modelling of CEACAM1 interactions in cell signalling
Abstract : CEACAM1, the primordial carcino-embryonic Ag gene family member, is a transmembrane cell adhesion molecule expressed in leukocytes, epithelia, and blood vessel endothelia. As a result of differential splicing, CEACAM1 occurs as several isoforms, the two major ones being CEACAM1-L and -S, that have long (L) or short (S) cytoplasmic domains, respectively. READ MORE
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4. Signal transduction pathways involved in PDGF receptor-induced cellular responses
Abstract : Platelet-derived growth factor (PDGF), is a potent connective tissue cell mitogen and chemoattractant which binds to two structurally related receptors denoted PDGF α- and β- receptors. Upon binding of PDGF to the receptor, signaling molecules containing Src Homology 2 (SH2) domains are recruited to the activated receptor and mediate propagation of the signal. READ MORE
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5. Biochemical and Structural Studies on the Adaptor Protein p130Cas
Abstract : Crk associated substrate (Cas) is an adaptor protein that becomes phosphorylated upon integrin signaling and influences regulation of cell processes such as migration, proliferation and survival. It consists of multiple domains and regions that can interact with several signaling proteins involved in different signaling pathways. READ MORE