Search for dissertations about: "SHP2"
Showing result 1 - 5 of 6 swedish dissertations containing the word SHP2.
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1. Protein kinases and phosphatases in B-cell lymphoma
Abstract : Around 2000 persons are diagnosed with lymphoma in Sweden each year. There are many subgroups described for this form of cancer and the great majority is derived from B-cells. The most common subgroup is Diffuse large B-cell lymphoma (DLBCL), a highly aggressive disease where only half of the patients are cured. READ MORE
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2. Control of neuronal survival, migration and outgrowth by GDNF and its receptors
Abstract : Glial cell line-derived neurotrophic factor (GDNF) is the prototypical member of a family of growth factors that are indispensable in nervous system development and maintenance. GDNF signals by binding to a multi-component receptor complex comprised of the ligand-binding subunit GFRα1 and the signaling subunit RET or NCAM. READ MORE
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3. Protein tyrosine phosphatases : taking a 'redoxionist' look at PDGFR signaling
Abstract : Protein Tyrosine Phosphatases (PTPs) are oxidized and inactivated by reactive oxygen species (ROS) upon stimulation of a wide range of cell surface receptors, including the platelet-derived growth factor (PDGF) receptor (PDGF R). Signaling via this receptor tyrosine kinase stimulates cell proliferation and migration, and it is associated with cancer and cardiovascular diseases. READ MORE
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4. Redox-regulation of PTPs : mechanisms and impact on PDGFR signaling
Abstract : Protein tyrosine phosphatases (PTPs) are reversibly oxidized upon activation of platelet-derived growth factor receptor beta (PDGFβR). Dys-regulation of the PDGFβR signaling pathway is associated with several diseases, including cancers and cardiovascular disease, and is thus a known driver of disease progression. READ MORE
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5. Role of FLT3 in Acute Myeloid Leukemia: Molecular mechanisms and Therapeutic opportunities
Abstract : Acute myeloid leukemia (AML) is a highly heterogeneous blood disease which is characterized by different mutations and chromosomal rearrangements. Nearly 60% of genetic alterations have been found in AML patients involve in signaling pathways including signaling of tyrosine kinase receptor FLT3. READ MORE